Adropin Antibody [DyLight 405] Summary
Immunogen |
Synthetic peptide made to an internal portion of human Adropin (within residues 10-60). [Swiss-Prot# Q6UWT2] |
Localization |
secreted. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
ENHO |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Reactivity Notes
88% sequence identity with bovine protein.
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
50mM Sodium Borate |
Preservative |
0.05% Sodium Azide |
Purity |
Immunogen affinity purified |
Notes
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for Adropin Antibody [DyLight 405]
Background
Adropin (energy homeostasis-associated protein, ENHO) is a peptide hormone encoded by gene ENHO and its unique ORF generates a 76-residue long secretary peptide which is highly conserved in eutherian (placental) mammals. Adropin is abundantly expressed in liver/brain, and in mouse, hepatic expression as well as circulating adropin concentrations exhibits rapid regulation by fasting (inhibition) and refeeding (stimulation), suggesting regulation through metabolic status signals. Mouse obesity models further confirmed that adropin is involved in metabolic homeostasis and cardiovascular function. Diet-induced as well as genetically induced obesity has been found to be associated with decreased hepatic adropin expression and circulating adropin concentrations. Adropin-knockout mice exhibit increased adiposity and fasting triglycerides (TG), hepatic steatosis, insulin resistance, and increased propensity for impaired glucose tolerance with diet-induced obesity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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