AdipoR1 Antibody

Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports the conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-28640	Applications	Species
Ma H, You GP, Cui F et al. Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD. Ann Hepatol. 2014-12-24 [PMID: 25536648] (IHC-P, WB, Rat)	IHC-P, WB	Rat
Takeuchi S, Wada K, Uozumi Y et al. Adiponectin receptor 1 expression is associated with carotid plaque stability. Neurol India 2013-05-01 [PMID: 23860143] (IHC-P, Human)	IHC-P	Human
De Rosa A, Monaco ML, Capasso M et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol 2013-04-23 [PMID: 23612446] (WB, Human)	WB	Human
Daniele A, De Rosa A, Nigro E et al. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. The International Journal of Biochemistry & Cell Biology. 2012-01-03 [PMID: 22233975]
Staiger,H et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes 53 (9), 195-2201. 2004-01-01 [PMID: 15331527]
Yamauchi,T et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects . Nature 423 (6941), 762-769. 2003-01-01 [PMID: 12802337]

Array NBP1-28640

• AdipoR1 Antibodies
• AdipoR1 ELISA Kit
• AdipoR1 Proteins