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XBP1 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

Order Details

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XBP1 Antibody [DyLight 550] Summary

Immunogen
A genomic peptide made to an internal region of the human XBP1 protein (within residues 100-250). [Swiss-Prot P17861]
Localization
Nucleus
Specificity
This antibody is specific for both XBP1s and XBP1u.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
XBP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for XBP1 Antibody [DyLight 550]

  • HTF
  • TREB5
  • X-box binding protein 1
  • X-box-binding protein 1
  • XBP1
  • XBP-1
  • XBP2
  • XBP2Tax-responsive element-binding protein 5

Background

X-box binding protein 1 (XBP1) is a transcription factor important in endoplasmic reticulum function and stress response. In inflammatory bowel disease, the malfunction of XBP1 is one of many contributing factors that affects the unfolded protein response and inflammation. In response to heat shock, XBP1 is erroneously spliced and several downstream proteins are resultantly mis-folded. While the effects of XBP1 issues are mainly evidenced in mucosal tissues as a response to mechanical or disease induced stress, it is also important in some brain development and cognitive ability formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for XBP1 Antibody (NBP1-77681R) (0)

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Secondary Antibodies

 

Isotype Controls

Additional XBP1 Products

Research Areas for XBP1 Antibody (NBP1-77681R)

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Blogs on XBP1.

IRE1 alpha Regulates Dendritic Cell Function in Response to Viral Infection
By Natalia Gurule, PhD What is IRE1 alpha?Inositol- requiring enzyme type 1 alpha (IRE1a) is a serine/threonine kinase that is one of the three transducers within the unfolded protein response (UPR) signalin...  Read full blog post.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.

IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.

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Bioinformatics

Gene Symbol XBP1