XBP1 Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

XBP1 (X-box binding protein 1 or TREB5), is a unique bZIP transcription factor whose active form is generated by a non-conventional splicing reaction upon disruption of homeostasis in endoplasmic reticulum (ER) and unfolded protein response (UPR) activation. Originally identified as a key regulator of MHC class II gene expression in B cells, XBP1 now is known as the most conserved signaling component of UPR and is critical for cell fate determination in response to ER stress. XBP1 is a nuclear transcription factor essential for hepatocyte growth, plasma cells differentiation, immunoglobulin secretion, and UPR cascade. XBP1 acts upon ER stress by activating UPR target genes via direct binding to UPRE (the UPR element). XBP1 binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N3[AT]T-3', and also to certain TPA response elements. XBP1 also binds to HLA DR-alpha promoter as well as to the Tax-responsive element of HTLV-I. XBP1 is up-regulated by ATF6 via direct binding to ERSE in response to ER stress. Genetic variations in XBP1 have been linked with susceptibility to major affective disorder type 7 (MAFD7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 5 applications: ChIP, FLOW, KD, WB, Western Blot.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using NBP1-77681	Applications	Species
Pauline de Zeeuw, Lucas Treps, Melissa García-Caballero, Ulrike Harjes, Joanna Kalucka, Carla De Legher, Katleen Brepoels, Kristel Peeters, Stefan Vinckier, Joris Souffreau, Ann Bouché, Federico Taverna, Jonas Dehairs, Ali Talebi, Bart Ghesquière, Johan Swinnen, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Peter Carmeliet The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells Communications Biology 2024-05-23 [PMID: 38783087]
Luis O Correa-Medero, Shayna E Jankowski, Hanna S Hong, Nicholas D Armas, Aditi I Vijendra, Mack B Reynolds, Garrett M Fogo, Dominik Awad, Alexander T Dils, Kantaro A Inoki, Reid G Williams, Annabelle M Ye, Nadezhda Svezhova, Francisco Gomez-Rivera, Kathleen L Collins, Mary X O'Riordan, Thomas H Sanderson, Costas A Lyssiotis, Shannon A Carty ER-associated degradation adapter Sel1L is required for CD8 + T cell function and memory formation following acute viral infection. Cell reports 2024-04-29 [PMID: 38687642]
Espina M, Di Franco N, Brañas-Navarro M et al. The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice Neurobiology of disease 2023-07-11 [PMID: 37442396] (WB, Mouse) Details: Dilution: 1:1000	WB	Mouse
Venkatesh P, Kumar S, Kumar N, et al. Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2 bioRxiv 2021-01-15 (WB, Porcine, Mouse)	WB	Porcine, Mouse
Nancy Ahuja, Shalini Gupta, Rashmi Arora, Ella Bhagyaraj, Drishti Tiwari, Sumit Kumar, Pawan Gupta Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson’s Life Science Alliance 2024-04-12 [PMID: 38609183]
Denolly S, Guo H, Martens M et al. Dengue virus NS1 secretion is regulated via importin-subunit ?1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin mBio 2023-09-13 [PMID: 37702492]
Lombardi S, Goldman AR, Tang HY et al. Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer Cancer research communications 2023-06-01 [PMID: 37377614] (ChIP, Human)	ChIP	Human
Pandit M, Kil YS, Ahn JH et al. Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells Nature communications 2023-05-05 [PMID: 37147330] (Western Blot, Mouse) Details: WB 1:1000	Western Blot	Mouse
Navas-Madro�al M, Almendra-Pegueros R, Puertas-Umbert L et al. Targeting mitochondrial stress with SS31 prevents experimental abdominal aortic aneurysm: crosstalk with ER stress British journal of pharmacology 2023-03-25 [PMID: 36964990] (WB, Mouse)	WB	Mouse
Stein D, Slobodnik Z, Tam B et al. 4-phenylbutyric acid-Identity crisis; can it act as a translation inhibitor? Aging Cell 2022-12-01 [PMID: 36373957]
Gebert M, Sobolewska A, Bartoszewska S et al. Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor Cellular and Molecular Life Sciences 2021-11-01 [PMID: 34636989] (Western Blot)	Western Blot
Lin J, Liu H, Fukumoto T et al. Targeting the IRE1 alpha /XBP1s pathway suppresses CARM1-expressing ovarian cancer Nature communications 2021-09-07 [PMID: 34493732] (WB, Human)	WB	Human
Al-Yacoub N, Colak D, Mahmoud Sa Et Al. Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis Communications biology 2021-07-16 [PMID: 34272480]
Pandey R, Bakay M, Strenkowski BP et al. JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice Scientific reports 2021-04-01 [PMID: 33795715] (WB, Mouse)	WB	Mouse
Gonnella R, Gilardini Montani MS, Guttieri L et al. IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation Biomedicines 2021-01-27 [PMID: 33513694] (KD, Human)	KD	Human
Garufi A, Federici G, Gilardini Montani Ms et Al. Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation Biomolecules 2020-03-03 [PMID: 32138264] (WB, Human)	WB	Human
Ma, X;Bi, E;Lu, Y;Su, P;Huang, C;Liu, L;Wang, Q;Yang, M;Kalady, MF;Qian, J;Zhang, A;Gupte, AA;Hamilton, DJ;Zheng, C;Yi, Q; Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment Cell Metab. 2019-04-18 [PMID: 31031094] (FLOW, Mouse)	FLOW	Mouse
Ciccia F, Accardo-Palumbo A, Rizzo A et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 2013-06-05 [PMID: 23740229]
Show All 18 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Armen Petrosyan	WB	Human	06/27/2023	View Summary Application Western Blot Sample Tested PC-3 Cells Species Human Lot D104146-2

Array NBP1-77681

• XBP1 Antibodies
• XBP1 ELISA Kits
• XBP1 Lysates
• XBP1 Proteins