XBP1 Products

Description

XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter.

Bioinformatics

Entrez	22433 Mouse 289754 Rat 7494 Human
Uniprot	AAH12841 Human BAB82982 Human NM_005080 Human NP_001073007 Human NP_001073007.1 Human NP_005071.2 Human O35426 Mouse P17861 Human
Product By Gene ID	7494
Alternate Names	TREB5 X-box binding protein 1 X-box-binding protein 1 XBP-1 XBP2Tax-responsive element-binding protein 5

Research Areas for XBP1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism
Unfolded Protein Response

Related XBP1 Blog Posts

Check out the latest blog posts on XBP1.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...    Read more.

IRE1 - an important sensor in the unfolded protein response pathway During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...    Read more.

IRE1 alpha Regulates Dendritic Cell Function in Response to Viral Infection By Natalia Gurule, PhD What is IRE1 alpha?Inositol- requiring enzyme type 1 alpha (IRE1a) is a serine/threonine kinase that is one of the three transducers within the unfolded protein response (UPR) signalin...    Read more.

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