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XBP1 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77681AF350
Alexa Fluor 405
NBP1-77681AF405
Alexa Fluor 488
NBP1-77681AF488
Alexa Fluor 532
NBP1-77681AF532
Alexa Fluor 594
NBP1-77681AF594
Alexa Fluor 647
NBP1-77681AF647
Alexa Fluor 700
NBP1-77681AF700
Alexa Fluor 750
NBP1-77681AF750
Allophycocyanin
NBP1-77681APC
Biotin
NBP1-77681B
CoraFluor 1
NBP1-77681CL1
DyLight 350
NBP1-77681UV
DyLight 405
NBP1-77681V
DyLight 550
NBP1-77681R
DyLight 594
NBP1-77681DL594
DyLight 650
NBP1-77681C
DyLight 680
NBP1-77681FR
DyLight 755
NBP1-77681IR
FITC
NBP1-77681F
HRP
NBP1-77681H
Janelia Fluor 525
NBP1-77681JF525
Janelia Fluor 549
NBP1-77681JF549
Janelia Fluor 646
NBP1-77681JF646
Janelia Fluor 669
NBP1-77681JF669
PE
NBP1-77681PE
PerCP
NBP1-77681PCP
Unconjugated
NBP1-77681
mFluor Violet 450 SE
NBP1-77681MFV450
mFluor Violet 500 SE
NBP1-77681MFV500
mFluor Violet 610 SE
NBP1-77681MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77681
BSA Free
NBP1-77681SS
BSA Free
NBP1-77681
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XBP1 Antibody [DyLight 488] Summary

Immunogen
A genomic peptide made to an internal region of the human XBP1 protein (within residues 100-250). [Swiss-Prot P17861]
Localization
Nucleus
Specificity
This antibody is specific for both XBP1s and XBP1u.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
XBP1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for XBP1 Antibody [DyLight 488]

  • HTF
  • TREB5
  • X-box binding protein 1
  • X-box-binding protein 1
  • XBP1
  • XBP-1
  • XBP2
  • XBP2Tax-responsive element-binding protein 5

Background

X-box binding protein 1 (XBP1) is a transcription factor important in endoplasmic reticulum function and stress response. In inflammatory bowel disease, the malfunction of XBP1 is one of many contributing factors that affects the unfolded protein response and inflammation. In response to heat shock, XBP1 is erroneously spliced and several downstream proteins are resultantly mis-folded. While the effects of XBP1 issues are mainly evidenced in mucosal tissues as a response to mechanical or disease induced stress, it is also important in some brain development and cognitive ability formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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XBP1 Antibody
[DyLight 488]
NBP1-77681G
XBP1 Antibody [DyLight 488]
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, KD

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Product General Protocols

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Video Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on XBP1.

Check out the latest blog posts on XBP1.
IRE1 alpha Regulates Dendritic Cell Function in Response to Viral Infection
By Natalia Gurule, PhD What is IRE1 alpha?Inositol- requiring enzyme type 1 alpha (IRE1a) is a serine/threonine kinase that is one of the three transducers within the unfolded protein response (UPR) signalin...  Read full blog post.
Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.
IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.
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Bioinformatics

Gene Symbol XBP1