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WRCH1 Antibody

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Immunohistochemistry-Paraffin: WRCH1 Antibody [NBP2-13230] - Staining of human bronchus shows strong membranous and cytoplasmic positivity in respiratory epithelial cells.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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WRCH1 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: LREDVKVLIELDKCKEKPVPEEAA
Predicted Species
Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RHOU
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
WRCH1 Protein (NBP2-13230PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for WRCH1 Antibody

  • ARHU
  • CDC42L1GTP-binding protein-like 1
  • DJ646B12.2
  • fJ646B12.2
  • FLJ10616,2310026M05Rik
  • G28K
  • GTP-binding protein like 1
  • GTP-binding protein SB128
  • hG28K
  • ras homolog gene family, member U
  • ras-like gene family member U
  • Rho GTPase-like protein ARHU
  • rho-related GTP-binding protein RhoU
  • Ryu GTPase
  • Wnt-1 responsive Cdc42 homolog 1
  • WRCH-1
  • WRCH1CDC42-like GTPase 1

Background

Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.; Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction > focal adhesion. Cell projection > podosome. Note: Localizes to podosomes in SRC-transformed cells.; Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol RHOU