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PKN1 Antibody

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Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications WB, IHC, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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PKN1 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 911-929 of human PKN1 (EAPTLSPPRDARPLTAAEQ) was used as immunogen; GenBank no. gi|914098|gb|AAB33345.1|.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PKN1
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:1000-1:5000
  • Immunoprecipitation 1:50-1:200
  • Western Blot 1:1000-1:2000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for PKN1 Antibody

  • DBK
  • EC 2.7.11
  • MGC46204
  • PAK1
  • PAK1Serine-threonine protein kinase N
  • PKN
  • PKN1
  • PKN-ALPHA
  • PKNPKN-ALPHA
  • PRK1
  • PRK1PAK-1
  • PRKCL1
  • PRKCL1protein kinase C-related kinase 1
  • Protease-activated kinase 1
  • Protein kinase C-like 1EC 2.7.11.13
  • Protein kinase C-like PKN
  • protein kinase N1
  • Protein kinase PKN-alpha
  • Protein-kinase C-related kinase 1
  • serine/threonine protein kinase N
  • serine/threonine-protein kinase N1
  • serine-threonine kinase N

Background

PKN1 is encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PKN1
Entrez
Uniprot