VPS35 Antibody (2D3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 9 of 9.

Publications using H00055737-M02	Applications	Species
Chelsie K, Anusha K, Austen M et al. Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. Mol Brain. 2021-09-16 [PMID: 34530877]
Abhishek M, Rodolfo Z, Vincent S et al. A new functional role of mitochondria-anchored protein ligase in peroxisome morphology in mammalian cells. J Cell Biochem. 2021-07-28 [PMID: 34322908]
Follett J, Fox JD, Gustavsson EK et al. DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of Sorting Nexin 1. Neurosci Lett. 2019-05-11 [PMID: 31082451]
Cataldi S, Follett J, Fox JD et al. Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice. NPJ Parkinsons Dis 2018-08-21 [PMID: 30155515]
Ayumu S, Sevan M, Prudent J, McBride H. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes Nature. [PMID: 28146471] (ICC/IF, Human)	ICC/IF	Human
Brigidi GS, Santyr B, Shimell J et al. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Nat Commun. 2015-09-03 [PMID: 26334723]
Munsie LN, Milnerwood AJ, Seibler P et al. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's Disease VPS35 mutation p.D620N. Hum Mol Genet. 2014-11-21 [PMID: 25416282]
Kang Yunhee, Ge Yuan, Cassidy Robert M et al. A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2. J Biol Chem. 2014-10-17 [PMID: 25190809] (Mouse)		Mouse
Prosser DC, Tran D, Schooley A et al. A Novel, Retromer-Independent Role for Sorting Nexins 1 and 2 in RhoG-Dependent Membrane Remodeling. Traffic. 2010-08-03 [PMID: 20604901]

Array H00055737-M02

• VPS35 Antibodies
• VPS35 ELISA Kit
• VPS35 Lysate
• VPS35 Proteins