SorLA Antibody (525122)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

SorLA (sortilin-related receptor, LDLR class A repeats-containing), also called LR11 or SORL1, is a 250 kDa type I transmembrane glycoprotein of the Sortilin family of Vps10p-domain receptors. SorLA is found in both intracellular and surface membranes in the central nervous system, and mediates trafficking of proteins such as the amyloid precursor protein (APP). The 2214 amino acid (aa) human SorLA includes a 28 aa signal sequence, a 53 aa furin-cleaved propeptide, and a 2056 aa extracellular domain. The region used as an immunogen, which includes BNR, LDLR class A and B, and EGF-like domains, but excludes fibronectin-like domains, shares 95% aa identity with mouse and rat SorLA.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB5699	Applications	Species
G Monti, M Kjolby, AMG Jensen, M Allen, J Reiche, PL Møller, R Comaposada, BE Zolkowski, C Vieira, MM Jørgensen, IE Holm, PN Valdmanis, N Wellner, CB Vægter, SJ Lincoln, A Nykjær, N Ertekin-Ta, JE Young, M Nyegaard, OM Andersen Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease Acta neuropathologica communications, 2021-03-16;9(1):43. 2021-03-16 [PMID: 33726851] (Western Blot, Human)	Western Blot	Human
T Zhou, J Zhan, W Fang, Y Zhao, Y Yang, X Hou, Z Zhang, X He, Y Zhang, Y Huang, L Zhang Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC) BMC Cancer, 2017-04-14;17(1):269. 2017-04-14 [PMID: 28410578] (IHC-P, Human)	IHC-P	Human

Array MAB5699

• SorLA Antibodies
• SorLA Protein
• SorLA Proteins and Enzymes