IGF-II R/IGF2R Antibody (2G11) - BSA Free

Mannose 6 phosphate is a sequence tag that plays a pivotal role in delivering proteins to the lysosome. Specifically, the mannose 6 phosphate sequence is tagged to N-linked oligosaccharides of lysosomal hydrolases as they pass through the cis-Golgi network. Once the lysosomal enzymes are tagged with the M6P sequence, they are destined to the late endosome by way of vesicular transport. After a low pH dissociates the M6P Receptor from its ligand, the M6P sequences are recycled. Additionally, M6P is bound by lectin in the immune system, and is converted to fructose 6-phosphate by mannose phosphate isomerase.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: FLOW, ICC/IF, IF/IHC, Immunohistochemistry, Immunohistochemistry-Frozen, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB300-514	Applications	Species
Calcagni' A, Staiano L, Zampelli N et al. Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation Nature communications 2023-07-03 [PMID: 37400440] (ICC/IF, FLOW)	ICC/IF, FLOW
Aguilar-GonzAlez A, GonzAlez-Correa JE, Barriocanal-Casado E et al. Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies International journal of molecular sciences 2022-06-04 [PMID: 35682977] (FLOW, Mouse)	FLOW	Mouse
Wang Q, Tao C, Hannan A et al. Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling Science Advances 2021-07-02 [PMID: 34193412] (Immunohistochemistry, Immunohistochemistry-Frozen)	Immunohistochemistry, Immunohistochemistry-Frozen
Muzio L, Sirtori R, Gornati D et al. Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis Nat Commun 2020-07-31 [PMID: 32737286] (IF/IHC, Mouse)	IF/IHC	Mouse
Kakegawa W, Katoh A, Narumi S et al. Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning Neuron 2018-08-08 [PMID: 30122381] (ICC/IF, Mouse)	ICC/IF	Mouse
Takahashi K, Mashima H, Miura K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci Rep. 2017-06-06 [PMID: 28588238] (IF/IHC, WB, Mouse)	IF/IHC, WB	Mouse
Ganley IG, Carroll K, Bittova L, Pfeffer S. Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. Mol Biol Cell. 2004-12-01 [PMID: 15456905] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Arighi CN, Hartnell LM, Aguilar RC et al. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004-04-01 [PMID: 15078903] (ICC/IF, Human)	ICC/IF	Human
Valdez AC, Cabaniols JP, Brown MJ, Roche PA. Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. J Cell Sci. 1999-03-01 [PMID: 10036234] (ICC/IF, Human)	ICC/IF	Human
Barker LP, George KM, Falkow S, Small PL. Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect Immun. 1997-04-01 [PMID: 9119492] (ICC/IF, Mouse)	ICC/IF	Mouse
Heinzen RA, Scidmore MA, Rockey DD, Hackstadt T. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun. 1996-03-01 [PMID: 8641784] (ICC/IF, Human)	ICC/IF	Human
Dintzis SM et al. Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. J Biol Chem 269:12159-66. 1994-01-01 [PMID: 8163521]
Show All 12 Publications. Collapse Publications.

Array NB300-514

• IGF-II R/IGF2R Antibodies
• IGF-II R/IGF2R Protein
• IGF-II R/IGF2R Proteins and Enzymes
• IGF-II R/IGF2R ELISA