Tryptase alpha/beta 1 Antibody (AA1)

Principal Names: Tryptase alpha/beta 1 Official Gene Symbol: TPSAB1 Gene ID: 7177 (Human) Gene Map Locus: 16p13.3 (Human). Human tryptases are divided into two groups, alpha and beta. beta-Tryptase appears to be the major type stored in mast cell secretory granules and alpha-tryptase is the major isoform expressed by basophils.beta-tryptase, a major constituent of mast cell secretory granules, has emerged recently as the most specific marker in vivo of mast cell activation in humans. It is a trypsin like serine protease that hydrolyzes peptide bonds on the C-terminal side of basic amino acids. Unlike trypsin, however, it is highly selective in hydrolyzing its peptide and protein targets and resists inactivation by circulating inhibitors. It has potential roles in the lung, skin, and other tissues as a local anticoagulant, activator of collagenase, promoter of smooth muscle contraction, and modulator of neuropeptide activity. The pathogenic role for tryptases has been observed in asthmatic airway inflammation other inflammatory disorders. The gene is mapped on human chromosome 16p13.3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: IF/IHC, IHC, IHC-P, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NBP2-26444	Applications	Species
Thomas K, Rao R, Rai S et al. Study of significance of bone marrow microvessel density in myeloproliferative neoplasms in correlation with CD34 blasts, mast cell count and fibrosis F1000Research 2023-05-16 (IHC, Human)	IHC	Human
Sharma G, Frei A, Fish B et al. Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury Frontiers in Physiology 2023-05-19 [PMID: 37275232] (IHC-P, Rat) Details: Dilution: 1:150	IHC-P	Rat
Awad-Igbaria Y, Dadon S, Shamir A et al. Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats Journal of inflammation research 2022-07-11 [PMID: 35845089]
Moriyama H, Endo J, Kataoka M et al. Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling Nature communications 2022-05-31 [PMID: 35641514] (IHC-P, Mouse)	IHC-P	Mouse
Cordner ZA, Li Q, Liu L et al. Vagal gut-brain signaling mediates amygdaloid plasticity, affect and pain in a functional dyspepsia model JCI insight 2021-02-16 [PMID: 33591956] (IF/IHC)	IF/IHC
Maiese A, Scopetti M, Santurro A et al. Corpse dismemberment: A case series. Solving the puzzle through an integrated multidisciplinary approach J Forensic Leg Med 2020-10-05 [PMID: 33012308]
Gao F, Fish BL, Szabo A et al. Enhanced survival from radiation pneumonitis by combined irradiation to the skin. Int. J. Radiat. Biol. 2014-05-14 [PMID: 24827855] (IHC-P, Rat)	IHC-P	Rat
Farkas D, Kraskauskas D, Drake JI et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit(+) cells in rats. PLoS ONE. 2014-03-03 [PMID: 24587052] (IHC-P, Rat)	IHC-P	Rat
Masaka T, Iijima K, Endo H et al. Gender differences in oesophageal mucosal injury in a reflux oesophagitis model of rats. Gut. 2013-01-01 [PMID: 22287598] (IHC-P, Rat) Details: Product cited: Mast Cell Tryptase (IMG-80250). IHC(paraffin): Normal and reflux esophagitis (RE) rat esophagus tissue: Fig S1.	IHC-P	Rat
Le BV, Khorsi-Cauet H, Bach V, Gay-Queheillard J. Mast cells mediate Pseudomonas aeruginosa lipopolysaccharide-induced lung inflammation in rat. Eur J Clin Microbiol Infect Dis. 2012-08-01 [PMID: 22282020] Details: Products cited: Mast Cell Tryptase (IMG-80250).
Shimada R, Nakao K, Furutani R, Kibayashi K. A rat model of changes in dural mast cells and brain histamine receptor H3 expression following traumatic brain injury. J Clin Neurosci. 2012-03-01 [PMID: 22277566] (IHC-P, Mouse) Details: Product Cited: Mast Cell Tryptase (IMG-80250). 1. IHC(paraffin): Mouse brain (Cerebral Cortex) with/out induced traumatic brain injury (TBI), Figure 1A & B.	IHC-P	Mouse
Sato Y, Harada K, Kizawa K et al. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease. Am J Pathol. 2005-01-01 [PMID: 15631999] (IHC-P, Rat) Details: IHC (paraffin): rat liver, Fig 3B inset.	IHC-P	Rat
Haase MG, Klawitter A, Baretton GB. IkappaBgamma is expressed in mast cells. Virchows Arch. 2004-11-01 [PMID: 15378359] (IHC-P, Rat) Details: IHC (paraffin): Fig 1 (rat lung tissue sections), Fig 2 (rat peritoneal macrophages).	IHC-P	Rat
Akiyoshi H, Terada T. Mast cell, myofibroblast and nerve terminal complexes in carbon tetrachloride-induced cirrhotic rat livers. J Hepatol. 1998-07-01 [PMID: 9696499] (IHC-P, Rat) Details: IHC (paraffin): rat liver (data described in Results section, page 114).	IHC-P	Rat
Walls AF, Jones DB, Williams JH et al. Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase. J Pathol. 1990-10-01 [PMID: 2250189] (IHC-P, WB, Human) Details: IHC (paraffin) in human: Fig 1 (skin), Fig 2 (lung), Fig 4 (A:bronchiole, B:lung alveoli, C:T-lymphocyte area of tonsil, D:septum of tonsil, E:colonic mucosa and F:skin), Table 1 (summary of staining in multiple tissues). Peripheral blood basophils were u	IHC-P, WB	Human
Show All 15 Publications. Collapse Publications.

Array NBP2-26444

• Tryptase alpha/beta 1 Antibodies
• Tryptase alpha/beta 1 Lysate
• Tryptase alpha/beta 1 Protein