NTH1 Antibody - BSA Free

NTH1 (endonuclease III-like protein 1 or NTHL1) has both apurinic/apyrimidinic endonuclease activity and a DNA N-glycosylase activity. The C-O-P bond 3' to apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. NTH1 associates with 1 4Fe-4S cluster and this cluster has been proposed to involve in proper positioning of enzyme along the DNA strand. With potential for incising damaged DNA at cytosines, thymines and guanines, NTH1 acts on a damaged strand 5' from the damaged site, for playing essential role in repair of both oxidative DNA damage and spontaneous mutagenic lesions. Localized in the nucleus, NTH1 is widely expressed with highest levels in heart and its expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 8 of 8.

Publications using NB100-108	Applications	Species
Limpose KL, Trego KS, Li Z et al. Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic Acids Res. 2018-03-07 [PMID: 29522130] (IHC-P, Human)	IHC-P	Human
Ma H, Wang J, Abdel-Rahman SZ Et cl. Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. Toxicol Appl Pharmacol 2013-01-23 [PMID: 23352893] (IHC-P, Rat)	IHC-P	Rat
Tarry-Adkins JL, Martin-Gronert MS, Fernandez-Twinn DS et al. Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart. FASEB J. 2013-01-01 [PMID: 23024373] (WB, Rat)	WB	Rat
Chang C-L, Ho M-C, Lee P-H et al. S1P5 is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. Am J Physiol Cell Physiol 297(2):C451-458. 2009-01-01 [PMID: 19474291] (WB, Human)	WB	Human
Goto M, Shinmura K, Igarashi H et al. Altered expression of the human base excision repair gene NTH1 in gastric cancer. Carcinogenesis 30(8):1345-1352. 2009-01-01 [PMID: 19414504] (IF/IHC, Human)	IF/IHC	Human
O'reilly, M et al. p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. Antioxid Redox Signal. 7(5-6):719-25. 2005-05-01 [PMID: 15890018]
Lindberg C, Eriksson C, Van Dam AM et al. Neuronal expression of caspase-1 immunoreactivity in the rat central nervous system. J Neuroimmunol 2004-01-01 [PMID: 14698852]
Wang AL, Lukas TJ et al. Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina. Neurobiol Aging. 31(11):2002-10. 2010-11-01 [PMID: 1908429] (IF/IHC, Mouse, Rat)	IF/IHC	Mouse, Rat

Array NB100-108

• NTH1 Antibodies
• NTH1 Protein