TRIM5 alpha Antibody - BSA Free

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NBP1-76600	Applications	Species
Richardson MW, Guo L, Xin F et al. Stabilized Human TRIM5alpha Protects Human T Cells From HIV-1 Infection. Mol. Ther. 2014-06-01 [PMID: 24662946] (WB, Human) Details: Human primary T cells transduced with lentiviral vectors encoding TRIM5 alpha isoforms, Fig 2A & D. The specificity of the TRIM5 alpha pAb was validated with TRIM5 lentiviral transduced T cells by WB (Fig 2A & D).	WB	Human

Array NBP1-76600

• TRIM5 alpha Antibodies
• TRIM5 alpha Protein