PML Protein Antibody - BSA Free

PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: FLOW, ICC/IF, IF/IHC, IP, KD, PLA, WB, Western Blot.

Showing Publications 1 - 10 of 46. Show All 46 Publications. Collapse Publications.

Publications using NB100-59787	Applications	Species
Iyer DP, Moyon L, Wittler L et Al. Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy Genome Res 2024-05-15 [PMID: 38719471]
Samuel Hofmann, Julius Luther, Verena Plank, Andreas Oswald, Julia Mai, Ilka Simons, Julija Miller, Valeria Falcone, Lea Hansen-Palmus, Hartmut Hengel, Michael Nassal, Ulrike Protzer, Sabrina Schreiner, Samuel K. Campos Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection Microbiology Spectrum 2024-05-01 [PMID: 38567974]
Fracassi C, Ugge' M, Abdelhalim M et al. PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer Nucleic acids research 2023-10-12 [PMID: 37823593] (WB, Human) Details: 1:1000 dilution	WB	Human
Hofmann S, Plank V, Groitl P et al. SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA Microbiology spectrum 2023-05-18 [PMID: 37199632]
Trier I, Black EM, Joo YK, Kabeche L ATR protects centromere identity by promoting DAXX association with PML nuclear bodies Cell reports 2023-05-30 [PMID: 37163376]
Göttig L, Wei beta C, Stubbe M et al. Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression mBio 2023-05-08 [PMID: 37154747] (WB, Human)	WB	Human
Roos K, Berkholz J LDL Affects the Immunomodulatory Response of Endothelial Cells by Modulation of the Promyelocytic Leukemia Protein (PML) Expression via PKC International journal of molecular sciences 2023-04-15 [PMID: 37108469] (WB, Human)	WB	Human
Huang D, Zhao D, Li M et al. Crosstalk between PML and p53 in response to TGF-?1: A new mechanism of cardiac fibroblast activation International journal of biological sciences 2023-01-22 [PMID: 36778116] (PLA, Mouse)	PLA	Mouse
Yan HY, Wang HQ, Zhong M et al. PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression Virologica Sinica 2021-05-27 [PMID: 34046815]
Lee J, Stone J, Desai P et al. Arsenicals, the Integrated Stress Response, and Epstein-Barr Virus Lytic Gene Expression Viruses 2021-04-30 [PMID: 33946406] (WB, Human)	WB	Human
Marks D, Heinen N, Bachmann L et al. Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load Acta neuropathologica communications 2021-04-13 [PMID: 33849647] (IF/IHC, Human)	IF/IHC	Human
Karle W, Becker S, Stenzel P et al. Promyelocytic leukemia protein (PML) promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries Clinical science (London, England : 1979) 2021-03-25 [PMID: 33764440]
Becker S, Steinemann G, Karle W et al. Stability of Smyd1 in endothelial cells is controlled by PML-dependent SUMOylation upon cytokine Stimulation Nature 2020-11-25 [PMID: 33241844]
Li K, Wang F, Yang ZN et Al. PML-RAR? interaction with TRIB3 impedes PPAR?/RXR function and triggers dyslipidemia in acute promyelocytic leukemia Theranostics 2020-01-01 [PMID: 32929351]
Grigore F, Yang H, Hanson ND et al. BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases Neoplasia 2020-07-03 [PMID: 32629178]
Wang M, Wang L, Qian M et Al. PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome Aging Cell 2020-04-29 [PMID: 32351002]
Hofmann S, Mai J, Masser S et Al. ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity Adv. Sci. 2020-02-27 [PMID: 32328411] (WB)	WB
Stubbe M, Mai J, Paulus C et Al. Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers mBio 2020-03-17 [PMID: 32184235] (ICC/IF, Human)	ICC/IF	Human
Chen YT, Ou Yang WT, Juang HH et al. Proteomic characterization of arsenic and cadmium exposure in bladder cells Rapid Commun. Mass Spectrom. 2019-09-09 [PMID: 31499585]
E Lång, A Po?e?, A Lång, M Valk, P Blicher, AD Rowe, KA Tønseth, CJ Jackson, TP Utheim, LMC Janssen, J Eriksson, SO Bøe Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding Nat Commun, 2018-09-10;9(1):3665. 2018-09-10 [PMID: 30202009]
Li K, Wang F et al. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RAR alpha and Inhibition of p53-Mediated Senescence. Cancer Cell 2017-08-05 [PMID: 28486108] (WB, Mouse)	WB	Mouse
LAng A, Eriksson J, Schink KO et al. Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites Nucleus. 2017-04-11 [PMID: 28402725] (FLOW, WB, KD, Human)	FLOW, WB, KD	Human
Ponente M, Campanini L, Cuttano R et al. PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. JCI Insight. 2017-02-23 [PMID: 28239645] (Western Blot)	Western Blot
Yao K, Wu Y, Chen Q et al. The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1 PLoS ONE 2016-09-14 [PMID: 27622275] (ICC/IF, Human)	ICC/IF	Human
Neumann F, Czech-Sioli M et al. Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies. J Gen Virol 2016-01-11 [PMID: 27580912] (WB, Human)	WB	Human
Komatsu T, Nagata K, Wodrich H. An adenovirus DNA replication factor, but not incoming genome complexes, targets PML nuclear bodies. J. Virol. 2015-11-25 [PMID: 26608315]
Burck C, Mund A, Berscheminski J et al. KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol 2015-11-04 [PMID: 26537675]
Berscheminski J, Brun J, Speiseder T et al. Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation. Oncogene 2015-10-19 [PMID: 26477309]
Wimmer P, Berscheminski J, Blanchette P et al. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2015-03-16 [PMID: 25772236] (ICC/IF, Human)	ICC/IF	Human
Chen HY, Hu JY, Chen TH et al. KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination Oncogene. 2015-01-26 [PMID: 25619834] (WB)	WB
Coltella N, Percio S, Valsecchi R et al. HIF factors cooperate with PML-RARalpha to promote acute promyelocytic leukemia progression and relapse. EMBO Mol Med. 2014-03-21 [PMID: 24711541] (IP, WB, Human)	IP, WB	Human
Palibrk V, Lang E, Lang A et al. Promyelocytic leukemia bodies tether to early endosomes during mitosis. Cell Cycle 2014-01-01 [PMID: 24675887] (Human)		Human
Berscheminski J, Wimmer P, Brun J et al. Sp100 isoform-specific regulation of human Adenovirus type 5 (Ad5) gene expression. J. Virol. 2014-03-12 [PMID: 24623443] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Schreiner S, Burck C, Glass M et al. Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res 2013-02-08 [PMID: 23396441] (WB, Human)	WB	Human
Berscheminski J, Groitl P, Dobner T et al. The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription J Virol 2012-11-07 [PMID: 23135708] (ICC/IF, Human)	ICC/IF	Human
Carracedo A, Weiss D, Leliaert AK et al. A metabolic prosurvival role for PML in breast cancer. J Clin Invest 2012-09-01 [PMID: 22886304]
Bade VN, Nickels J, Keusekotten K et al. Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. PLoS One 2012-01-01 [PMID: 22693631]
Chiantore MV, Vannucchi S, Accardi R et al. Interferon-beta induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity. PLoS One 2012-01-01 [PMID: 22615843]
Sivachandran N, Wang X, Frappier L et al. Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection. J Virol 2012-06-01 [PMID: 22491455]
Sivachandran N, Dawson CW, Young LS et al. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. J Virol 2012-01-01 [PMID: 22013060]
Everett RD. Study of early events during herpes simplex virus type 1 infection by confocal microscopy. Methods 2011-10-01 [PMID: 21855636]
Freudenberger N. Role of minor core protein V during productive infection with human adenovirus type 5 and the proteins relevance to oncogenic transformation processes Thesis 2017-01-01 (ICC/IF, Human)	ICC/IF	Human
Jung et al. The alphaherpesvirus serine/threonine kinase us3 disrupts promyelocytic leukemia protein nuclear bodies. J Virol. 2011-06-01 [PMID: 21430051]
Lee AK, Smart JL, Rubinstein M et al. Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes. Endocrinology 2011-05-01 [PMID: 21343252] (Mouse)		Mouse
Sivachandran N, Cao JY, Frappier L et al. Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. J Virol 2010-11-01 [PMID: 20719947]
Wimmer P, Schreiner S, Everett RD et al. SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. Oncogene 2010-10-07 [PMID: 20639899]
Show All 46 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Human	12/08/2011	View Summary Application Western Blot Sample Tested Human Species Human

Array NB100-59787

• PML Protein Antibodies
• PML Protein ELISA Kits
• PML Protein Lysate
• PML Protein Proteins