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TREX1 Antibody

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Immunocytochemistry/ Immunofluorescence: TREX1 Antibody [NBP2-68672] - Staining of human cell line HeLa shows localization to cytosol.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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TREX1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: VDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSRE
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TREX1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
Application Notes
Recommended conditions: Fixation/Permeabilization: PFA/Triton X-100
Control Peptide
TREX1 Recombinant Protein Antigen (NBP2-68672PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for TREX1 Antibody

  • 3'-5' exonuclease TREX1
  • AGS1
  • Aicardi-Goutieres syndrome 1
  • CRV
  • DKFZp434J0310
  • DNase III
  • DRN3
  • EC 3.1.11.2
  • HERNS
  • three prime repair exonuclease 1,3' repair exonuclease 1

Background

TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for TREX1 Antibody (NBP2-68672) (0)

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Secondary Antibodies

 

Isotype Controls

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Research Areas for TREX1 Antibody (NBP2-68672)

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Blogs on TREX1.

Dinosaur Protein Names: Infographic
Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn...  Read full blog post.

Trex1 (3'-5' exonuclease TREX1, DNase III)
This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui...  Read full blog post.

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Bioinformatics

Gene Symbol TREX1