Tie-2 Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

TIE2 (tyrosine-protein kinase receptor TIE-2) is an endothelial-selective RTK that is essential to angiopoietin (ANGPT)/TIE2 system which constitutes transmembrane endothelial tyrosine kinase TIE2 and its circulating ligands (ANGPT-1, -2 and ANGPT-3, -4). Activation/phosphorylation state of TIE2 regulates the baseline endothelial quiescence and its response to pathogens as well as cytokines, and TIE2 phosphorylation is largely controlled by the ratio of agonistic ligand ANGPT-1 and competitive inhibitor ANGPT-2. TIE2 exists as homodimer or heterodimer (with TIE1) and interacts with ANGPT1, ANGPT2, ANGPT4, TEK , TNIP2, SHC1, PTPRB, DOK2, GRB2, GRB7, GRB14, PIK3R1 and PTPN11/SHP2 etc for exerting its diverse biological functions. TIE2 regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion, actin cytoskeleton reorganization, and maintenance of vascular quiescence. It exerts anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels, and activates or inhibits angiogenesis, depending on the context (inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts). Targeted deletion of TIE2 or its major agonist ligand, Angpt-1, results in embryonic lethality in mice characterized by defects in blood vessel maturation, lack of recruitment of supporting pericytes and impaired basement membrane formation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-69753	Applications	Species
Shao, L;Sottoriva, K;Palasiewicz, K;Zhang, J;Hyun, J;Soni, SS;Paik, NY;Gao, X;Cuervo, H;Malik, AB;Rehman, J;Lucas, D;Pajcini, KV; A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche Haematologica 2019-03-28 [PMID: 30923091] (WB, Mouse)	WB	Mouse
Liu C, Tang J, Li C et al. PADI4 Stimulates Esophageal Squamous Cell Carcinoma Tumor Growth and Up-regulates CA9 Expression. Mol. Carcinog. 2018-09-22 [PMID: 30242913] (IF/IHC, Human)	IF/IHC	Human
Sun L, Zhang H, Bi L et al. Angiopoietin-1 facilitates recovery of hematopoiesis in radiated mice. Am J Transl Res 2016-06-27 [PMID: 27347310] (IF/IHC, Mouse)	IF/IHC	Mouse

Array NBP1-69753

• Tie-2 Antibodies
• Tie-2 Antibody Pair
• Tie-2 Lysate
• Tie-2 Protein
• Tie-2 ELISAs
• Tie-2 Proteins and Enzymes