Reactivity | HuSpecies Glossary |
Applications | IHC, IHC-P |
Clone | TIA1/1352R |
Clonality | Monoclonal |
Host | Rabbit |
Conjugate | DyLight 488 |
Immunogen | Human bone marrow malignant cells from a non B, non T acute leukemia |
Localization | Cytoplasmic granule, Nucleus, Accumulates in cytoplasmic stress granules (SG) following cellular damage |
Specificity | This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies. |
Isotype | IgG |
Clonality | Monoclonal |
Host | Rabbit |
Gene | TIA1 |
Purity | Protein A purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Protein A purified |
Secondary Antibodies |
Isotype Controls |
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Gene Symbol | TIA1 |