TGF-beta RI/ALK-5 Antibody [Biotin] Summary
Immunogen |
Mouse myeloma cell line NS0-derived recombinant human TGF-beta RI/ALK-5 Leu34-Glu125 Accession # P36897 |
Specificity |
Detects human TGF-beta RI/ALK-5 in Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse TGF-beta RI and less than 5% cross-reactivity with recombinant human (rh) TGF-beta RII and rhTGF-beta RIII is observed. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Goat |
Gene |
TGFBR1 |
Purity |
Antigen Affinity-purified |
Purity Statement |
Antigen Affinity-purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Purity |
Antigen Affinity-purified |
Reconstitution Instructions |
Reconstitute at 0.2 mg/mL in sterile PBS. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Background
Human TGF-beta RI (also ALK5) is a 55 kDa member of the Ser/Thr kinase family of transmembrane proteins. It is a type I membrane glycoprotein that is 479 amino acids (aa) in length. The short 101 aa extracellular domain (ECD) contains multiple cysteines and one potential N-linked glycosylation site. It is ubiquitously expressed, and forms a functional heterotetrameric TGF-beta receptor with TGF-beta RII. TGF-beta binding to TGF-beta RII phosphorylates TGF-beta RI, which then activates SMAD transcriptional proteins. The human TGF-beta RI ECD is 91%, 90%, 91%, and 93% aa identical to the TGF-beta RI ECD in pig, mouse, cow and rat, respectively.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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