TDP-43/TARDBP Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

TARDBP (tar-DNA binding protein of 43) is a nucleic acids binding protein that regulates the process of transcription and splicing. Localized mainly in the nucleus, TARDBP is ubiquitously expressed with higher expression levels in pancreas, placenta, lung, genital tract and spleen, and has been suggested to implicate in microRNA biogenesis, cellular apoptosis as well as proliferation. TARDBP controls CFTR splicing and promotes CFTR exon 9 skipping by associating with UG repeated motifs in polymorphic region near 3'-splice site of this exon leading to aberrant splicing linked to pathological features typical of cystic fibrosis. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Moreover, it stabilizes the low molecular weight neurofilament mRNA through a direct interaction with the 3' UTR. TARDBP was originally identified as a major protein component of the ubiquitin immuno-positive inclusions which are the pathologic substrate of common forms of ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), and later, it was found that TARDBP gene mutations are inherited in an autosomal dominant manner in familial/sporadic ALS. TARDBP has also been involved in other neurodegenerative such as Alzheimer's and Parkinson's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB110-55376V

• TDP-43/TARDBP Antibodies
• TDP-43/TARDBP ELISA Kits
• TDP-43/TARDBP Lysate
• TDP-43/TARDBP Proteins
• TDP-43/TARDBP Proteins and Enzyme