p62/SQSTM1 Antibody (2C11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

p62/SQSTM1 (ubiquitin-binding protein p62/Sequestrosome-1) is an intracellular protein (theoretical molecular weight 47.7 kDa) which localizes to the cytoplasm, nucleus, autophagosomes and lysosomes in all tissues (1). Structurally, p62/SQSTM1 consists of multiple domains (e.g., Phox1 and Bem1p-PB1, zinc finger-ZZ, TRAF6 binding domain-TB, Keap1-interacting region-KIR, LC3 interacting region-LIR and ubiquitin-associated domain-UBA) for interaction with various protein targets. Additional domains include nuclear export (NES) and nuclear localization signals (NLS1 and NLS2). p62/SQSTM1 is a multifunctional scaffold protein which forms oligomers with itself or with other proteins through interactions with PB1 domains.

Abnormal function of p62/SQSTM1 is associated with a range of disease states such as neurodegeneration, cancer, and metabolic disorders (2). Mutations in the p62/SQSTM1 sequence have been linked to Paget's disease of the bone, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. In Parkinson's disease, p62/SQSTM1 has been linked to microglia activation and subsequent neuroinflammation (3). Functionally, p62/SQSTM1 is involved in a broad range of cellular processes such as amino acid sensing by interaction with mTORC1, oxidative stress response through interaction with Keap1, and targeting cargo for autophagy by interacting with ubiquitin labeled proteins (1).

To induce selective autophagy, p62/SQSTM1 forms long oligomers or helical filaments which interact with LC3 and ubiquitin labeled proteins and lead to the initiation of the autophagosome formation (2). p62/SQSTM1 is not only a selective autophagy receptor but also an autophagy substrate, as its engulfed by the autophagosome and degraded by the autophagolysosome. Monitoring LC3 levels is the standard for assessing autophagic flux, however monitoring p62/SQSTM1 levels by Western blot in the presence and absence of autophagy inhibitors (e.g., Chloroquine) is also a common practice (4). Besides its activity as a selective autophagy receptor, p62/SQSTM1 also plays a role as an adaptor in signaling cascades leading to NFkB activation downstream of TNF-R, IL-1 beta R, TrkA and p75NTR. Briefly, for NFkB signaling downstream of the TNF-R activation, p62/SQSTM1 engages RIP1 kinase and PKC iota/lambda through the ZZ and PB1 domains, respectively (5).

References

1.Katsuragi, Y., Ichimura, Y., & Komatsu, M. (2015). P62/SQSTM1 functions as a signaling hub and an autophagy adaptor. FEBS Journal. https://doi.org/10.1111/febs.13540

2. Sanchez-Martin, P., & Komatsu, M. (2018). p62/SQSTM1 - Steering the cell through health and disease. Journal of Cell Science. https://doi.org/10.1242/jcs.222836

3. Yao, L., Zhu, Z., Wu, J., Zhang, Y., Zhang, H., Sun, X., ... Lu, G. (2019). MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. The FASEB Journal. https://doi.org/10.1096/fj.201900363r

4 Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., ... Zughaier, S. M. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. https://doi.org/10.1080/15548627.2015.1100356

5. Bitto, A., Lerner, C. A., Nacarelli, T., Crowe, E., Torres, C., & Sell, C. (2014). p62/SQSTM1 at the interface of aging, autophagy, and disease. Age. https://doi.org/10.1007/s11357-014-9626-3

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Rabbit.

We have publications tested in 9 applications: B/N, BA, IB, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 412. Show All 412 Publications. Collapse Publications.

Publications using H00008878-M01	Applications	Species
Shih-Hong Khoo, Pei-Ru Wu, Kun-Tu Yeh, Shih-Lan Hsu, Chi-Hao Wu Biological and clinical significance of the AGE-RAGE axis in the aggressiveness and prognosis of prostate cancer Journal of Food and Drug Analysis 2023-01-01 [PMID: 38526823]
Ainhoa Martínez-Pizarro, Sara Picó, Arístides López-Márquez, Claudia Rodriguez-López, Elena Montalvo, Mar Alvarez, Margarita Castro, Santiago Ramón-Maiques, Belén Pérez, José J Lucas, Eva Richard, Lourdes R Desviat PAH deficient pathology in humanized c.1066-11G>A phenylketonuria mice Human Molecular Genetics 2024-06-15 [PMID: 38520741]
Shannon Nicolson, Jantina A. Manning, Yoon Lim, Xin Jiang, Erica Kolze, Sonia Dayan, Ruchi Umargamwala, Tianqi Xu, Jarrod J. Sandow, Andrew I. Webb, Sharad Kumar, Donna Denton The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy Communications Biology 2024-02-15 [PMID: 38360932]
Xiaosen Ouyang, Willayat Y. Wani, Gloria A. Benavides, Matthew J. Redmann, Hai Vo, Thomas van Groen, Victor M. Darley-Usmar, Jianhua Zhang Cathepsin D overexpression in the nervous system rescues lethality and A beta 42 accumulation of cathepsin D systemic knockout in vivo Acta Pharmaceutica Sinica. B 2023-07-20 [PMID: 37799377]
Lee B, Kim YH, Lee W et al. USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes Free radical biology & medicine 2023-11-01 [PMID: 37776917] (BA, Human)	BA	Human
Siddique T, Chen W, Deng H et al. Molecular Targets for ALS and Related Disorders. United States Patent Application Mar 17 2016
Ko SH, Choi JH, Kim JM. Bacteroides fragilis Enterotoxin Induces Autophagy through an AMPK and FoxO3-Pathway, Leading to the Inhibition of Apoptosis in Intestinal Epithelial Cells Toxins (Basel) 2023-09-03 [PMID: 37755970]
Stuard Sambhariya W, Trautmann IJ, Robertson DM Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin The Journal of biological chemistry 2023-09-08 [PMID: 37690686] (WB, Human)	WB	Human
Leduc-Gaudet J, Miguez K, Cefis M et al. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. iScience 2023-07-01 [PMID: 37588163] (WB, Mouse)	WB	Mouse
Tamargo-Gómez I, Martínez-García GG, Suárez MF et al. Analysis of ATG4C function in vivo Autophagy 2023-07-17 [PMID: 37459465]
Calcagni' A, Staiano L, Zampelli N et al. Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation Nature communications 2023-07-03 [PMID: 37400440] (WB)	WB
Tejwani L, Jung Y, Kokubu H et al. Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration Journal of Clinical Investigation 2023-08-15 [PMID: 37384409]
Iemolo A, De Risi M, Giordano N et al. Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy NPJ Parkinson's disease 2023-06-16 [PMID: 37328503] (B/N)	B/N
Mengzhen Y, Bing H, Jiajia L et al. Coronaviral ORF6 protein mediates inter-organelle contacts and modulates host cell lipid flux for virus production. EMBO J. 2023-05-23 [PMID: 37218505]
Jianbin W, Andreas Z, Nils B et al. Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity. Transl Psychiatry. 2023-05-03 [PMID: 37137886]
Lee E, Jung Y, Park Y et al. A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis Nature Aging 2022-08-01 [PMID: 37118130] (IHC-Fr, Mouse)	IHC-Fr	Mouse
S Mukhopadhy, J Encarnació, EY Lin, ASW Sohn, H Zhang, JD Mancias, AC Kimmelman Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer Science Advances, 2023-04-19;9(16):eadf9284. 2023-04-19 [PMID: 37075122]
Tracy H, Sierra C, Alder L et al. STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease. Cells. 2023-03-23 [PMID: 37048051]
Xuan T, Kun C, Jiajia L et al. Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication. Cell Rep. 2023-03-10 [PMID: 36952345]
Shahin S, Lu B, Zhou Y et al. MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model iScience 2023-02-01 [PMID: 36936780] (IHC, WB, Mouse)	IHC, WB	Mouse
Vidyadhara DJ, Somayaji M, Wade N et al. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease Cell reports 2023-03-28 [PMID: 36920906] (IHC-Fr, WB, Mouse) Details: Dilution used in WB 1:1,000, IHC-Fr 1:200	IHC-Fr, WB	Mouse
Francois G, Eric B, William R et al. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Mol Cell. 2023-03-09 [PMID: 36898370]
Julien B, Leanne H, Sofia H et al. Modifying Dietary Protein Impacts mTOR Signaling and Brain Deposition of Amyloid ? in a Knock-In Mouse Model of Alzheimer Disease. J Nutr. 2023-03-03 [PMID: 36870538]
Southwell N, Zhao D, Sayles NM et al. High fat diet ameliorates the mitochondrial cardiomyopathy of CHCHD10 mutant mice bioRxiv 2023-02-22 [PMID: 36865125]
MJ Corenblum, A McRobbie-J, E Carruth, K Bernard, M Luo, LJ Mandarino, S Peterson, D Billheimer, T Maley, ED Eggers, L Madhavan Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine Neurons bioRxiv : the preprint server for biology, 2023-02-12;0(0):. 2023-02-12 [PMID: 36798207]
Williams JA, Ni HM, Ding Y et al. Parkin Regulates Mitophagy and Mitochondrial Function to Protect Against Alcohol-induced Liver Injury and Steatosis in Mice. American Journal of Physilogy Jul 9 2015
Hui Q, Xiaojuan C, Shaogui W et al. Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice. Cell Mol Gastroenterol Hepatol. 2023-02-06 [PMID: 36754207]
Pablo S, Franziska K, Ludovico A et al. ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. J Cell Sci. 2023-02-09 [PMID: 36644903]
Yi L, Michael T, Liang H et al. In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-I?B? Interaction That Underscore a Critical Role of p62 in Limiting NF-?B Activation Through I?B? Stabilization. Mol Cell Proteomics. 2023-01-10 [PMID: 36634736]
Guo L, Reed K, Carter A et al. Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation Cells 2022-12-30 [PMID: 36611953] (WB, Mouse)	WB	Mouse
Charlotte G, Alix S, Marie B et al. Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies. Brain. 2022-12-23 [PMID: 36562127]
Inoue M, Noguchi S, Inoue YU et al. Distinctive chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4 Acta neuropathologica 2023-02-01 [PMID: 36512060]
Yunash M, Raghbendra D, Jinbae S et al. Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion. Cell Commun Signal. 2022-11-25 [PMID: 36434621]
Caitlin L, Erica M, Jeanelle A et al. Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue. Methods Mol Biol. 2022-11-19 [PMID: 36399262]
Jingyi C, Xiaozhe Z, Shan G et al. A Beclin 1-targeting stapled peptide synergizes with erlotinib to potently inhibit proliferation of non-small-cell lung cancer cells. Biochem Biophys Res Commun. 2022-10-20 [PMID: 36332474]
Qu W, Jeong A, Zhong R et al. Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer's Mice Molecular neurobiology 2022-10-26 [PMID: 36287323]
Sang-Won P, Pureum J, Akinori Y et al. Development of new tools to study membrane-anchored mammalian Atg8 proteins. Autophagy. 2022-10-17 [PMID: 36250672]
Kim YS, Ko B, Kim DJ et al. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D Nature communications 2022-10-14 [PMID: 36241614]
Alba N, Irene F, Jordi R et al. Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology. NPJ Parkinsons Dis. 2022-10-06 [PMID: 36202848]
Sofia A, Pablo M, Steffen H et al. OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metab. 2022-09-15 [PMID: 36113464]
Baytas O, Kauer J, Morrow E Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus Neurobiology of Disease 2022-07-01 [PMID: 35908744] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Charles T, Gianni G Prolonged proteasome inhibition antagonizes TGF?1-dependent signalling by promoting the lysosomal-targeting of TGF? receptors. Cell Signal. 2022-07-25 [PMID: 35901932]
Akwa Y, Di Malta C, Zallo F et al. Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies Autophagy 2022-07-22 [PMID: 35867714]
Silva-Rojas R, P�rez-Gu�rdia L, Lafabrie E et al. Silencing of the Ca(2+) Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice International Journal of Molecular Sciences 2022-06-23 [PMID: 35805973]
Bojana K, Tihana B, Alexander S et al. Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1. Mol Cell. 2022-06-28 [PMID: 35793674]
Yang S, Liu T, Hu C et al. Ginsenoside Compound K Protects against Obesity through Pharmacological Targeting of Glucocorticoid Receptor to Activate Lipophagy and Lipid Metabolism Pharmaceutics 2022-06-02 [PMID: 35745765]
Ki-Tae J, Seon-Hee O The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker. Exp Mol Med. 2022-05-27 [PMID: 35624155]
Sinem D, Yunus A, S?la T et al. A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep. 2022-05-17 [PMID: 35581289]
Xiao X, Philip. C, Mei X et al. A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux. Biochem Pharmacol. 2022-05-02 [PMID: 35513042]
Huang H, Ouyang Q, Mei K et al. Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion Autophagy 2022-04-24 [PMID: 35465820] (WB, Human)	WB	Human
Shahin S, Xu H, Lu B et al. AAV-CRISPR/Cas9 Gene Editing Preserves Long-Term Vision in the P23H Rat Model of Autosomal Dominant Retinitis Pigmentosa Pharmaceutics 2022-04-09 [PMID: 35456659] (IF/IHC)	IF/IHC
Del Giudice R, Imbimbo P, Pietrocola F et al. Autophagy Alteration in ApoA-I Related Systemic Amyloidosis International journal of molecular sciences 2022-03-23 [PMID: 35408859] (WB, Human)	WB	Human
Xiaopeng X, Sumati H, Lyndsay Y et al. Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer. Cell Death Differ. 2022-03-24 [PMID: 35332310]
Zuleika L, Basim R, Andrew W et al. Free fatty acid treatment of mouse preimplantation embryos demonstrates contrasting effects of palmitic acid and oleic acid on autophagy. Am J Physiol Cell Physiol. 2022-03-23 [PMID: 35319901]
Van H, Gloria B, Michelle J et al. Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration. Mol Brain. 2022-03-05 [PMID: 35248135]
Vessey KA, Jobling AI, Tran MX et al. Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E) Autophagy 2022-02-23 [PMID: 35196199]
Da L, Jeong P, Yu L et al. PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway. Redox Biol. 2022-01-14 [PMID: 35091323]
Yancheng T, Liming W, Tao Y et al. Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharm Sin B. 2021-06-16 [PMID: 35024319]
Hui Q, Qingyun B, Xiao Y et al. Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice. Acta Pharm Sin B. 2021-11-16 [PMID: 35024307]
Vankrunkelsven W, Derde S, Gunst J et al. Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin Journal of cachexia, sarcopenia and muscle 2022-01-07 [PMID: 34994068] (WB, Mouse)	WB	Mouse
Quanhui T, Jie C, Gao G et al. Adenovirus vector encoding TPPII ignites HBV-specific CTL response by activating autophagy in CD8+T cell. J Viral Hepat. 2021-12-13 [PMID: 34902200]
Sabine W, Catherine W, Ieva A et al. Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy. Biochem Pharmacol. 2021-11-12 [PMID: 34780750]
Francois-Xavier T, Benjamin L, Ari S et al. P62 accumulates through neuroanatomical circuits in response to tauopathy propagation. Acta Neuropathol Commun. 2021-11-02 [PMID: 34727983]
Xiaojuan C, Shaogui W, Madeline H et al. Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. Am J Pathol. 2021-10-27 [PMID: 34717896]
Shaogui W, Xiaojuan C, Xiaoxiao J et al. Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice. Autophagy. 2021-10-28 [PMID: 34709991]
Millarte V, Schlienger S, KAlin S, Spiess M Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1 EMBO reports 2021-10-26 [PMID: 34704340]
Peng Z, Zhao C, Du X Et al. Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of alpha M beta 2 Integrin in Dairy Cows With Fatty Liver Frontiers in immunology 2021-10-07 [PMID: 34691032]
Cheng Y, Kim WK, Wellman LL Et al. Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner Life (Basel, Switzerland) 2021-10-16 [PMID: 34685469] (Mouse)		Mouse
Taneli H, Timo B, Juha K et al. Global Rhes knockout in the Q175 Huntington's disease mouse model. PLoS One. 2021-10-14 [PMID: 34648564]
Andreas B, Laura T, William H et al. Autophagy, TERT, and mitochondrial dysfunction in hyperoxia. Am J Physiol Heart Circ Physiol. 2021-09-24 [PMID: 34559580]
LS Alves, ARA Marques, N Padrão, FA Carvalho, J Ramalho, C Lopes, MIL Soares, CE Futter, TMVD Pinho E Me, NC Santos, OV Vieira Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis Journal of Cell Science, 2021-10-22;0(0):. 2021-10-22 [PMID: 34528688]
Hua S, Hong-Min N, Jennifer M et al. Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver Res. 2021-03-19 [PMID: 34504721]
Pelaz SG, Ollauri-Ib��ez C, Lillo C, Tabernero A. Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43(266-283) in Glioblastoma Stem Cells Cancers (Basel) 2021-08-24 [PMID: 34503072] (ICC/IF)	ICC/IF
Yin S, Shengfeng X, Natalie N et al. Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression. Biochem Biophys Res Commun. 2021-08-31 [PMID: 34482023]
Yamina H, Francois-Xavier M, Marine M et al. Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis. Cell Rep Med. 2021-08-17 [PMID: 34467247]
Yueyue L, Qiaoying H, Zijian W et al. GSK-3 mediates nuclear translocation of p62/SQSTM1 in MPTP-induced mouse model of Parkinson's disease. Neurosci Lett. 2021-08-13 [PMID: 34400288]
Silva-Rojas R, Charles A, Djeddi S Et Al. Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure Cells 2021-07-08 [PMID: 34359900]
Bellanger D, Dziagwa C, Guimaraes C et al. Adipocytes Promote Breast Cancer Cell Survival and Migration through Autophagy Activation Cancers (Basel) 2021-08-03 [PMID: 34359819] (WB, B/N)	WB, B/N
Dulac M, Leduc-Gaudet Jp, Cefis M Et Al. Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice The Journal of physiology 2021-07-16 [PMID: 34269418]
Hou K, Shen J, Yan J Et Al. Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin EBioMedicine 2021-07-01 [PMID: 34233258] (WB, IF/IHC)	WB, IF/IHC
Annadurai A, Nhat N, Arjun S et al. NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human ?-Synuclein Overexpressing Mice. Aging Dis. 2021-07-01 [PMID: 34221542]
Fontaine A, Bellanger D, Guibon R Et Al. Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue The Journal of pathology 2021-07-05 [PMID: 34219239] (WB)	WB
Kiyotoshi S, Yukitoshi T, Motohiko S et al. Loss of FYCO1 leads to cataract formation. Sci Rep. 2021-07-02 [PMID: 34215815]
Benito-Cuesta I, Ordonez-Gutierrez L, Wandosell F Trehalose Reduces the Secreted Beta-Amyloid Levels in Primary Neurons Independently of Autophagy Induction Metabolites 2021-06-26 [PMID: 34206776] (WB)	WB
Towers CG, Wodetzki DK, Thorburn J et al. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy Developmental Cell 2021-07-01 [PMID: 34171288]
Hao Chen, Katherine E. Williams, Elaine Y. Kwan, Mirhan Kapidzic, Kenisha A. Puckett, Rayyan K. Aburajab, Joshua F. Robinson, Susan J. Fisher Global proteomic analyses of human cytotrophoblast differentiation/invasion Development (Cambridge, England) 2021-07-01 [PMID: 34121116]
K Goel, EL Beatman, N Egersdorf, A Scruggs, D Cao, EV Berdyshev, KS Schweitzer, I Petrache Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy Cells, 2021-05-14;10(5):. 2021-05-14 [PMID: 34068927]
Sokhna Y, Mario R, Saray C et al. The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress. Cell Biol Toxicol. 2021-05-31 [PMID: 34060004]
Wojnarowicz PM, Escolano MG, Huang YH et al. Anti-tumor effects of an ID antagonist with no observed acquired resistance NPJ breast cancer 2021-05-24 [PMID: 34031428]
OJ Sul, G Li, JE Kim, ES Kim, HS Choi 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts: 7-KC in osteoclasts The Journal of nutritional biochemistry, 2021-05-21;0(0):108783. 2021-05-21 [PMID: 34023424]
Charles T, Evelyn N, Craig C et al. p62/Sequestosome 1 regulates transforming growth factor beta signaling and epithelial to mesenchymal transition in A549 cells. Cell Signal. 2021-05-14 [PMID: 34000385]
Jie L, Yanmei Q, Joshua C et al. CREG1 promotes lysosomal biogenesis and function. Autophagy. 2021-05-08 [PMID: 33966596]
Joanna P, Andrew M, Christophe P et al. Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. Am J Respir Cell Mol Biol. 2021-05-15 [PMID: 33662226]
Y Mu, Y Maharjan, R Kumar Dutt, X Wei, JH Kim, J Son, C Park, R Park Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell PLoS ONE, 2021-02-19;16(2):e0245799. 2021-02-19 [PMID: 33606716]
Robichaud S, Fairman G, Vijithakumar V et al. Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells Autophagy 2021-02-26 [PMID: 33590792]
Lihua H, Andrew K, Scott H et al. DNAJB12 and Hsp70 Triage Arrested Intermediates of N1303K-CFTR for ER Associated-Autophagy. Mol Biol Cell. 2021-02-03 [PMID: 33534640]
Recasens-Alvarez C, Alexandre C, Kirkpatrick J, et al. Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition Nature cell biology 2021-01-25 [PMID: 33495632]
Wang F, Zhang Y, Shen J, et al. The ubiquitin E3 ligase TRIM21 promotes hepatocarcinogenesis by suppressing the p62-Keap1-Nrf2 antioxidant pathway Cellular and molecular gastroenterology and hepatology 2021-01-19 [PMID: 33482392] (WB, IHC-P, ICC/IF, Mouse)	WB, IHC-P, ICC/IF	Mouse
Naho N, Chiaki I, Takako O et al. Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner. Sci Rep. 2021-01-18 [PMID: 33462315]
Park J, Choi H, Kim YD, et al. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation Molecular psychiatry 2021-01-15 [PMID: 33452442]
Shouzi Z, Yuanyuan W, Lixin L et al. Case Report of a pathologically confirmed vascular parkinsonism with early cognitive impairment and Behavioral disturbance. BMC Neurol. 2021-01-11 [PMID: 33430818]
Dong X, Yang Y, Zou Z et al. Sorting nexin 5 mediates virus-induced autophagy and immunity Nature 2020-12-16 [PMID: 33328639]
Hyun-Young L, Seon-Hee O Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Biochem Biophys Res Commun. 2020-12-13 [PMID: 33321290]
Zhao Y, Zou Z, Sun D et al. GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex Autophagy 2020-11-23 [PMID: 33222586]
Shireen S, Hetal S, Gil K et al. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Mol Cell. 2020-11-17 [PMID: 33207181]
Tara F, Chunxin W, Benjamin P et al. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain. J Cell Biol. 2020-12-07 [PMID: 33201170]
Bensalem J, Hattersley KJ, Hein LK et al. Measurement of autophagic flux in humans: an optimized method for blood samples PLoS One 2020-11-05 [PMID: 33164641]
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Crabtree D, Boyer-Guittaut M, Ouyang X et al. Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neurosci Lett. 2013-01-21 [PMID: 23391753]
Joubert R, Vignaud A, Le M et al. Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle. Hum Mol Genet. 2013-05-01 [PMID: 23390130] (WB, Mouse)	WB	Mouse
Mader BJ, Pivtoraiko VN, Flippo HM et al. Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death. ACS Chem. Neurosci. 2012-12-19 [PMID: 23259041]
Pan JA, Fan Y, Gandhirajan RK, Madesh M, Zong WX. Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis. J Biol Chem. [PMID: 23239879] (WB)	WB
Zeng X, Carlin CR. Host Cell Autophagy Modulates Early Stages of Adenovirus Infections in Airway Epithelial Cells. J Virol. 2012-12-12 [PMID: 23236070]
Gan L, Vargas MR, Johnson DA, Johnson JA. Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model. J Neurosci. 2012-12-05 [PMID: 23223297]
Fetalvero KM, Yu Y, Goetschkes M et al. Defective autophagy and mTORC1 signaling in myotubularin null mice. Mol Cell Biol. 2013-01-01 [PMID: 23109424] (ICC/IF, Mouse)	ICC/IF	Mouse
Zhang Y, Yang ND, Zhou F et al. (-)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization. PLoS One. 2012-10-08 [PMID: 23056433]
Liao CC, Ho MY, Liang SM, Liang CM. Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration. Autophagy. 2013-01-01 [PMID: 23051912]
Vandergaast R, Fredericksen BL. West Nile Virus (WNV) Replication Is Independent of Autophagy in Mammalian Cells. PLoS One. 2012-09-21 [PMID: 23029249]
Williams JA, Thomas AM, Li G et al. Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor. PLoS One. 2012-08-27 [PMID: 22952826]
Kharaziha P, De Raeve H, Fristedt C et al. Sorafenib has potent anti-tumor activity in multiple myeloma in vitro, ex vivo and in vivo, in the 5T33MM mouse model. Cancer Res. 2012-08-24 [PMID: 22952216]
Elrick MJ, Yu T, Chung C, Lieberman AP. Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease Hum Mol Genet 2012-08-23 [PMID: 22872701] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Cannizzo ES, Clement CC, Morozova K et al. Age-Related Oxidative Stress Compromises Endosomal Proteostasis Cell Rep 2012-07-26 [PMID: 22840404] (WB, Mouse)	WB	Mouse
Ramos FJ, Chen SC, Garelick MG et al. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med. 2012-07-25 [PMID: 22837538] (WB, Mouse)	WB	Mouse
Lai AY, McLaurin J. Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease Biochim Biophys Acta 2012-07-16 [PMID: 22800931] (WB, Mouse)	WB	Mouse
Hagemann TL, Jobe EM, Messing A. Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. PLoS One. 2012-01-01 [PMID: 22693571] (WB)	WB
Marchbank K, Waters S, Roberts RG et al. Marchbank K, Waters S, Roberts RG et al. MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network Int J Cell Biol 2012-05-10 [PMID: 22654911] Details: Chlorocebus sabaeus (Green monkey)
Ni HM, Boggess N, McGill MR et al. Liver-specific loss of atg5 causes persistent activation of nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci. 2012-04-05 [PMID: 22491424]
Menon S, Yecies JL, Zhang HH et al. Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice. Sci Signal. 2012-03-27 [PMID: 22457330]
Durieux AC, Vassilopoulos S, Laine J et al. A centronuclear myopathy-dynamin 2 mutation impairs autophagy in mice. Traffic. 2012-02-28 [PMID: 22369075]
Ghazi-Noori S, Froud KE, Mizielinska S et al. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012-03-01 [PMID: 22366797]
Jaber N, Dou Z, Chen JS et al. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A. 2012-01-23 [PMID: 22308354]
Kharaziha P, Rodriguez P, Li Q et al. Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells. Cell Death Dis. 2012-01-26 [PMID: 22278289]
Chen J, Xavier S, Moskowitz-Kassai E et al. Cathepsin Cleavage of Sirtuin-1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence. Am J Pathol. 2012-01-09 [PMID: 22234173]
Kruger U, Wang Y, Kumar S, Mandelkow EM. Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol Aging. 2011-12-12 [PMID: 22169203]
Ohmi K, Zhao H-Z, Neufeld EF. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS ONE 20116(11). [PMID: 22096577]
Zois CE, Giatromanolaki A, Sivridis E et al. Autophagic flux in normal mouse tissues: focus on endogenous LC3A processing. Autophagy 2011-11-01 [PMID: 21997374] (WB, Mouse)	WB	Mouse
Deng HX, Chen W, Hong ST et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 2011-08-21 [PMID: 21857683]
Levy JM, Thorburn A. Modulation of pediatric brain tumor autophagy and chemosensitivity. J Neurooncol. 2011-08-13 [PMID: 21842312]
Li H, Wang P, Sun Q et al. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res. 4140-01-01 [PMID: 21444671] (WB, Human)	WB	Human
Yang S, Wang X, Contino G et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011-03-15 [PMID: 21406549]
Karanasios E, Ktistakis NT. Studying Autophagy: List of Useful Antibodies Produced via a Community Effort. Autophagy at the Cell, Tissue and Organismal Level. 2016-04-24
Kovacs JR, Li C, Yang Q et al. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ. 2011-06-10 [PMID: 21660048]
Zois CE, Giatromanolaki A, Kainulainen H et al. Lung autophagic response following exposure of mice to whole body irradiation, with and without amifostine. Biochem Biophys Res Commun 2011-01-07 [PMID: 21145309]
Harr MW, McColl KS, Zhong F et al. Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes Autophagy 2010-10-01 [PMID: 20814235] (WB, Mouse)	WB	Mouse
Whitehouse CA, Waters S, Marchbank K et al. Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity. Proc Natl Acad Sci U S A 107(29):12913-8. 2010-07-20 [PMID: 20616007]
Deng HX, Zhai H, Bigio EH et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol 2010-06-01 [PMID: 20517935] (IF/IHC)	IF/IHC
Wang B, Ling S, Lin WC. 14-3-3Tau regulates Beclin 1 and is required for autophagy. PLoS One 2010-01-01 [PMID: 20454448]
Lee HK, Mattei LM, Steinberg BE et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 32(2):227-39. 2010-02-26 [PMID: 20171125]
Wu YT, Tan HL, Shui G et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285(14):10850-61. 2010-04-02 [PMID: 20123989]
Mardakheh FK, Yekezare M, Machesky LM, et al. Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. J Cell Biol. 2009-10-12 [PMID: 19822672]
Ferguson CJ, Lenk GM, Meisler MH. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum Mol Genet;18(24):4868-78. 2009-12-15 [PMID: 19793721]
Gal J, Strom AL, Kwinter DM et al. Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. J Neurochem 111(4):1062-73. 2009-11-01 [PMID: 19765191]
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Jung HS, Chung KW, Won Kim J et al. Loss of Autophagy Diminishes Pancreatic b Cell Mass and Function with Resultant Hyperglycemia. Cell Metab. 2008-10-01 [PMID: 18840362]
Show All 412 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Erika Geisbrecht	Immunohistochemistry + Western Blot	Drosophila	08/21/2023	View Summary Application Other Sample Tested dissected carcass for muscle staining,drosophila larvae,drosophila larval muscle,whole drosophila larvae Species Drosophila Lot N7131-2C11 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** Drosophila muscle staining with the Novus antibody did not match the staining with a published antibody against drosophila ref(2)p (the drosophila equivalent of p62). Western blot with the Novus antibody did not show any bands with drosophila whole larval samples. Immunohistochemistry with fixed drosophila larval tissue Western blot with drosophila whole larval samples
	5 reviewed by: Verified Customer	ICC	Human	01/24/2022	View Summary Application Immunocytochemistry Sample Tested Hela cell line Species Human Lot 2C11
Enlarge	4 reviewed by: Verified Customer	WB	Human	08/17/2019	View Summary Application Western Blot Sample Tested HEK293 Species Human Lot H5191-2C11 Comments Comments 60ug of total cell lysate was loaded for the KO screening. There were several non-specific bands below 50Kda region.
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	12/18/2017	View Summary Application Western Blot Sample Tested Mouse embryonic fibroblasts Species Mouse Lot H5191-2C11 Comments Comments p62 knockout mouse embryonic fibroblasts Name: Anti-p62 antibody (H00008878-M01) Catalog #: Anti-p62 antibody (H00008878-M01) Lot Number: Anti-p62 antibody (H00008878-M01, Lot # H5191-2C11) PO/Order Number: Click here to enter text.. WB Image Description (Please provide labels for all lanes): lane 1: WT mouse embryonic fibroblasts; lane 2: p62 knockout mouse embryonic fibroblasts Sample Information:      Cell Line or Tissue: mouse embryonic fibroblasts;      Species: mouse      Treatment: No treatment Lysate Preparation:      Date of lysate preparation: December 15, 2017      Lysis buffer used: 1X lysis buffer from Cell Signaling by adding PMSF Reducing agent: beta-mercaptoethanol, DTT If boiled (temperature/time): Yes Controls:      Positive Control: Wild type      Negative Control: Knockout      Loading Control (please attach additional images if applicable): No Protein Amount Loaded per lane: 20 ug Antibody Storage Conditions: -20℃ Electrophoresis: Gel Percentage: 8% Electrophoresis Conditions: Tris-Glycine-SDS at room temperature      Voltage: 120V      Time: 2 hours Membrane Transfer:      Method (Submersion/Semi-dry): wet transfer      Membrane Type (PVDF/Nitrocellulose): Nitrocellulose      Time: 2 hours      Voltage: 100V Blocking:      Blocking Solution: 5% milk in 1X TBST      Time: 1 hour at room temperature Primary Antibody:      Dilution: 1/1000      Diluent Buffer: 2.5% BSA      Incubation Time: overnight      Incubation Temperature: 4℃ Washing Conditions:      Wash Solution: 1X TBST      Time and Repetitions: 5 min each for 3 times Secondary Antibody Manufacturer and Catalog #: Promega, W402B, Lot # 0000191071 Secondary description: goat anti-mouse secondary antibody      Dilution: 1/2000      Diluent Buffer: 3% milk      Incubation Time: 1 hour      Incubation Temperature: room temperature Detection Method: Detection: ECL (GE, cat # RPN2209, lot # 9838243) Procedure: Add equal volume of A and B, mix and apply on the membranes for 3-5 min before exposure Development Time: 20 seconds Molecular weight of band(s): ~ 65 kDa Experimental Concerns and Observations: A specific band around 65 kDa was observed
	5 reviewed by: Woojong Lee	WB	Mouse	05/04/2017	View Summary Application Western Blot Sample Tested DEndritic cell lysate Species Mouse
Enlarge	5 reviewed by: Verified Customer	IF	Human	04/05/2016	View Summary Application Immunofluorescence Sample Tested Differentiated cell line Species Human
Enlarge	5 reviewed by: Fabrice GANKAM	WB	Rat	11/01/2014	View Summary Application Western Blot Sample Tested Rat brain Species Rat
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	10/24/2014	View Summary Application Western Blot Sample Tested mouse hepatocytes and HepG2 cells Species Mouse
Enlarge	5 reviewed by: Nadine Bakkar	IP	Human	08/07/2014	View Summary Application Immunoprecipitation Sample Tested Human spinal cord cytoplasmic homogenates Species Human
	3 reviewed by: Lin Zhang	WB	Mouse	09/28/2011	View Summary Application Western Blot Sample Tested Mouse Species Mouse

Array H00008878-M01

• p62/SQSTM1 Antibodies
• p62/SQSTM1 ELISA Kit
• p62/SQSTM1 Lysate
• p62/SQSTM1 Proteins