TDP-43/TARDBP Antibody (JM51-10) Summary
Additional Information |
Recombinant Monoclonal Antibody |
Immunogen |
Synthetic peptide within Human TDP-43/TARDBP aa 354-390 / 414; (2)aa 253-290 / 414. (SwissProt: Q13148 Human; SwissProt: Q921F2 Mouse; Unigene:2633 Rat; Entrez Gene:325052 Zebrafish) |
Localization |
Cytoplasm, Mitochondrion, Nucleus. |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
TARDBP |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry 1:50-1:100
- Immunocytochemistry/ Immunofluorescence 1:100-1:500
- Immunohistochemistry
- Immunohistochemistry-Frozen 1:100
- Immunohistochemistry-Paraffin 1:50-1:200
- Immunoprecipitation Use at an assay dependent concentration.
- Western Blot 1:500-1:5000
|
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
TBS (pH7.4), 0.05% BSA, 40% Glycerol |
Preservative |
0.05% Sodium Azide |
Concentration |
1 mg/ml |
Purity |
Protein A purified |
Alternate Names for TDP-43/TARDBP Antibody (JM51-10)
Background
TARDBP, also known as TAR DNA binding protein, is a DNA and RNA-binding protein which regulates transcription and splicing. TARDBP is also involved in the regulation of CFTR splicing and promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TARD-BP may also be involved in microRNA biogenesis, apoptosis and cell division. TARDBP can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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