Immunohistochemistry-Paraffin: TAP2 Antibody [NBP1-89312] - Staining of human tonsil shows strong cytoplasmic positivity in cells in seminiferus ducts.
This antibody was developed against Recombinant Protein corresponding to amino acids: GSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TAP2
Purity
Immunogen affinity purified
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Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (81%), Rat (81%). Reactivity reported in scientific literature (PMID: 23435261)
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for TAP2 Antibody
ABC18
ABCB3
ABCB3ABC18
antigen peptide transporter 2
APT2
ATP-binding cassette, sub-family B (MDR/TAP), member 3
D6S217E
MHC 2
Peptide transporter involved in antigen processing 2
Peptide transporter PSF2
Peptide transporter TAP2
PSF2
PSF2PSF-2
Really interesting new gene 11 protein
RING11
RING11ATP-binding cassette sub-family B member 3
TAP2
transporter 2, ABC (ATP binding cassette)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Y1
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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