ST2/IL-33R Antibody (245707) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ST2, also known as IL-33R, IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Mouse ST2 consists of a 306 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 23 aa transmembrane segment, and a 212 aa cytoplasmic domain with an intracellular TIR domain (3). Alternate splicing of the 120 kDa mouse ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions (3). Within the ECD, mouse ST2 shares 68% and 81% aa sequence identity with human and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (4‑7). It binds IL-33, a cytokine that is up‑regulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (4, 8). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 9, 10). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (6). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (4, 11‑13). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (5, 7, 14). Soluble ST2 functions as a decoy receptor that blocks IL-33's ability to signal through transmembrane ST2 (9, 12‑14).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Flow Cytometry, In Vivo, Neutralization.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB10041	Applications	Species
Jiajia Tan, Jing Wei, Hongxiang Lu sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-beta 1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis Inflammation 8/1/2023 [PMID: 37036563]
Lu Wang, Yan Luo, Liping Luo, Dandan Wu, Xiaofeng Ding, Handong Zheng et al. Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling Journal of Experimental Medicine 2/1/2021 [PMID: 33104171]
J Huang, MA Gandini, L Chen, S M'Dahoma, PL Stemkowski, H Chung, DA Muruve, GW Zamponi Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk Cell Rep, 2020-10-06;33(1):108233. 2020-10-06 [PMID: 33027646] (Neutralization, Mouse)	Neutralization	Mouse
Z He, J Song, J Hua, M Yang, Y Ma, T Yu, J Feng, B Liu, X Wang, Y Li, J Li Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons Cell Death Dis, 2018-12-05;9(12):1173. 2018-12-05 [PMID: 30518915] (Neutralization, Mouse)	Neutralization	Mouse
M Walker, J Green, R Ferrie, A Queener, MH Kaplan, JM Cook-Mills Mechanism for Initiation of Food Allergy: Dependence on skin barrier mutations and environmental allergen co-stimulation J. Allergy Clin. Immunol., 2018-02-15;0(0):. 2018-02-15 [PMID: 29454836] (In Vivo, Mouse)	In Vivo	Mouse
Y Ito, N Schaefer, A Sanchez, D Francisco, R Alam, RJ Martin, JG Ledford, C Stevenson, D Jiang, L Li, M Kraft, HW Chu Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice J Innate Immun, 2018-01-27;0(0):. 2018-01-27 [PMID: 29393212] (Neutralization, Mouse)	Neutralization	Mouse
IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy Proc. Natl. Acad. Sci. U.S.A., 2016-11-07;0(0):. 2016-11-07 [PMID: 27821781] (Neutralization, Mouse)	Neutralization	Mouse
Kumamoto Y, Linehan M, Weinstein J, Laidlaw B, Craft J, Iwasaki A CD301b(+) dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity, 2013-09-26;39(4):733-43. 2013-09-26 [PMID: 24076051] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Neutralization, Mouse)	Neutralization	Mouse
Ohno T, Oboki K, Morita H Paracrine IL-33 Stimulation Enhances Lipopolysaccharide-Mediated Macrophage Activation. PLoS ONE, 2011-04-11;6(4):e18404. 2011-04-11 [PMID: 21494550] (Flow Cytometry, Neutralization, Mouse)	Flow Cytometry, Neutralization	Mouse
Ashley M. Miller, Darren L. Asquith, Axel J. Hueber, Lesley A. Anderson, William M. Holmes, Andrew N. McKenzie et al. Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice Circulation Research 9/3/2010 [PMID: 20634488]
Show All 11 Publications. Collapse Publications.

Array MAB10041

• ST2/IL-33R Antibodies
• ST2/IL-33R Antibody Pair
• ST2/IL-33R ELISA Kit
• ST2/IL-33R Proteins
• ST2/IL-33R ELISAs
• ST2/IL-33R Proteins and Enzymes