ST2/IL-33R Antibody (245707) [Allophycocyanin] Summary
Immunogen |
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ST2/IL-33 R Ser27-Arg332 Accession # P14719 |
Specificity |
Detects mouse ST2/IL-33 R in ELISAs. |
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Rat |
Gene |
Il1rl1 |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Packaging, Storage & Formulations
Storage |
Protect from light. Do not freeze.- 12 months from date of receipt, 2 to 8 °C as supplied.
|
Buffer |
Supplied in a saline solution containing BSA and Sodium Azide. |
Preservative |
Sodium Azide |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Background
ST2, also known as IL-33R, IL-1 R4 and T1, is an
Interleukin-1 receptor family glycoprotein that contributes to Th2 immune
responses (1, 2). Mouse ST2 consists of a 306 amino acid (aa) extracellular
domain (ECD) with three Ig-like domains, a 23 aa transmembrane segment, and a
212 aa cytoplasmic domain with an intracellular TIR domain (3). Alternate
splicing of the 120 kDa mouse ST2 generates a soluble 60 kDa isoform that lacks
the transmembrane and cytoplasmic regions (3). Within the ECD, mouse ST2 shares
68% and 81% aa sequence identity with human and rat ST2, respectively. ST2 is
expressed on the surface of mast cells, activated Th2 cells, macrophages, and
cardiac myocytes (4‑7). It binds IL-33, a cytokine that is up‑regulated
by inflammation or mechanical strain in smooth muscle cells, airway epithelia,
keratinocytes, and cardiac fibroblasts (4, 8). IL-33 binding induces the
association of ST2 with IL-1R AcP, a shared signaling subunit that also
associates with IL-1 RI and IL-1 R rp2 (1, 9, 10). In macrophages, ST2
interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor
proteins MyD88 and Mal (6). In addition to its role in promoting mast cell and
Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception
and protects from atherosclerosis and cardiac hypertrophy (4, 11‑13).
The soluble ST2 isoform is released by activated Th2 cells and strained cardiac
myocytes and is elevated in the serum in allergic asthma (5, 7, 14). Soluble
ST2 functions as a decoy receptor that blocks IL-33's ability to signal through
transmembrane ST2 (9, 12‑14).
- Barksby, H.E. et al. (2007) Clin. Exp. Immunol. 149:217.
- Gadina, M. and C.A. Jefferies (2007) Science STKE 2007:pe31.
- Yanagisawa, K. et al. (1993) FEBS Lett. 318:83.
- Schmitz, J. et al. (2005) Immunity 23:479.
- Lecart, S. et al. (2002) Eur. J. Immunol. 32:2979.
- Brint, E.K. et al. (2004) Nat. Immunol. 5:373.
- Weinberg, E.O. et al. (2002) Circulation 106:2961.
- Sanada S. et al. (2007) J. Clin. Invest. 117:1538
- Palmer, G. et al. (2008) Cytokine 42:358.
- Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
- Allakhverdi, Z. et al. (2007) J. Immunol. 179:2051.
- Verri Jr., W.A. et al. (2008) Proc. Natl. Acad. Sci. 105:2723.
- Miller, A.M. et al. (2008) J. Exp. Med. 205:339.
- Hayakawa, H. et al. (2007) J. Biol. Chem. 282:26369.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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