Home » ST2/IL-33R » ST2/IL-33R Antibodies » ST2/IL-33R Antibody (245707) [Alexa Fluor® 700]
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ST2/IL-33R Antibody (245707) [Alexa Fluor® 700]

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P815 mouse mastocytoma cell line was stained with Rat Anti-Mouse ST2/IL-33 R Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB10041N, filled histogram) or isotype control antibody (IC013N, open histogram). View our protocol for Staining Membrane-associated Proteins.
P815 mouse mastocytoma cell line was stained with Rat Anti-Mouse ST2/IL-33 R Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB10041N, filled histogram) or isotype control antibody (IC013N, open ...read more
Raw264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse ST2/IL-33 R Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB10041N, filled histogram) or isotype control antibody (IC013N, ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
245707
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 700

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB10041U-100UG
Alexa Fluor 405
FAB10041V-100UG
Alexa Fluor 488
FAB10041G-100UG
Alexa Fluor 532
FAB10041X
Alexa Fluor 594
FAB10041T-100UG
Alexa Fluor 647
FAB10041R-100UG
Alexa Fluor 750
FAB10041S-100UG
Allophycocyanin
FAB10041A-100UG
Allophycocyanin
FAB10041A-025UG
Allophycocyanin/Cy7
FAB10041APCCY7
Biotin
FAB10041B
CoraFluor 1
FAB10041CL1
DyLight 350
FAB10041D
DyLight 405
FAB10041E
DyLight 488
FAB10041K
DyLight 550
FAB10041L
DyLight 594
FAB10041M
DyLight 650
FAB10041W
DyLight 680
FAB10041Y
DyLight 755
FAB10041Z
FITC
FAB10041F
HRP
FAB10041H
Janelia Fluor 525
FAB10041JF525
Janelia Fluor 549
FAB10041I
Janelia Fluor 646
FAB10041J
Janelia Fluor 669
FAB10041JF669
PE/Atto594
FAB10041PEATT594
PE/Cy5.5
FAB10041PECY55
PE/Cy7
FAB10041PECY7
PerCP
FAB10041C
Phycoerythrin
FAB10041P-100UG
Unconjugated
MAB10041-100
mFluor Violet 450 SE
FAB10041MFV450
mFluor Violet 500 SE
FAB10041MFV500
mFluor Violet 610 SE
FAB10041MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB10041-100
Carrier Free
MAB10041-SP
Carrier Free
MAB10041-100
Carrier Free
MAB10041-500
Carrier Free
FAB10041V-100UG
Carrier Free
FAB10041U-100UG
Carrier Free
FAB10041T-100UG
Carrier Free
FAB10041S-100UG
Carrier Free
FAB10041R-100UG
Carrier Free
FAB10041A-100UG
Carrier Free
FAB10041A-025UG
Carrier Free
FAB10041G-100UG
Carrier Free
FAB10041P-100UG
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ST2/IL-33R Antibody (245707) [Alexa Fluor® 700] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ST2/IL-33 R
Ser27-Arg332
Accession # P14719
Specificity
Detects mouse ST2/IL-33 R in ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
Il1rl1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 5 uL/10^6 cells
Publications
Read Publications using
FAB10041N in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ST2/IL-33R Antibody (245707) [Alexa Fluor® 700]

  • DER4
  • DER4ST2growth stimulation-expressed
  • Fit-1
  • IL-1 R4
  • IL1R4
  • IL-1R4
  • IL-1RL1
  • IL-33 R
  • IL33R
  • IL-33R
  • interleukin 1 receptor-like 1
  • interleukin 1 receptor-related protein
  • interleukin-1 receptor-like 1
  • Ly84
  • MGC32623
  • Protein ST2
  • ST2
  • ST2L
  • ST2V
  • T1
  • T1homolog of mouse growth stimulation-expressed

Background

ST2, also known as IL-33R, IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses (1, 2). Mouse ST2 consists of a 306 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 23 aa transmembrane segment, and a 212 aa cytoplasmic domain with an intracellular TIR domain (3). Alternate splicing of the 120 kDa mouse ST2 generates a soluble 60 kDa isoform that lacks the transmembrane and cytoplasmic regions (3). Within the ECD, mouse ST2 shares 68% and 81% aa sequence identity with human and rat ST2, respectively. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes (4‑7). It binds IL-33, a cytokine that is up‑regulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts (4, 8). IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2 (1, 9, 10). In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal (6). In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy (4, 11‑13). The soluble ST2 isoform is released by activated Th2 cells and strained cardiac myocytes and is elevated in the serum in allergic asthma (5, 7, 14). Soluble ST2 functions as a decoy receptor that blocks IL-33’s ability to signal through transmembrane ST2 (9, 12‑14).

  1. Barksby, H.E. et al. (2007) Clin. Exp. Immunol. 149:217.
  2. Gadina, M. and C.A. Jefferies (2007) Science STKE 2007:pe31.
  3. Yanagisawa, K. et al. (1993) FEBS Lett. 318:83.
  4. Schmitz, J. et al. (2005) Immunity 23:479.
  5. Lecart, S. et al. (2002) Eur. J. Immunol. 32:2979.
  6. Brint, E.K. et al. (2004) Nat. Immunol. 5:373.
  7. Weinberg, E.O. et al. (2002) Circulation 106:2961.
  8. Sanada S. et al. (2007) J. Clin. Invest. 117:1538
  9. Palmer, G. et al. (2008) Cytokine 42:358.
  10. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
  11. Allakhverdi, Z. et al. (2007) J. Immunol. 179:2051.
  12. Verri Jr., W.A. et al. (2008) Proc. Natl. Acad. Sci. 105:2723.
  13. Miller, A.M. et al. (2008) J. Exp. Med. 205:339.
  14. Hayakawa, H. et al. (2007) J. Biol. Chem. 282:26369.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ST2/IL-33R
Antibody (245707) [Al ...
FAB10041N
ST2/IL-33R Antibody (245707) [Alexa Fluor® 700]
Species: Mu
Applications: Flow

Publications for ST2/IL-33R Antibody (FAB10041N)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


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Bioinformatics

Gene Symbol Il1rl1
Uniprot