SREBP1 Antibody

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB100-74542	Applications	Species
Dahlhoff C, Worsch S, Sailer M et al. Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels Mol Metab. 2014-08-01 [PMID: 25061561] (WB, Mouse) Details: BHMT antibody used for WB on liver tissue lysates of eight week-old male C57BL/6NCrl mice subjected to the following dietary regimns - control, high-fat, , control/methyl-donor supplemented group/CMS and high fat methyl-donor supplemented/HFMS animals (Figure 4).	WB	Mouse

Array NB100-74542

• SREBP1 Antibodies
• SREBP1 Kit
• SREBP1 Lysates
• SREBP1 Proteins