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SR-BI Antibody [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-99690AF350
Alexa Fluor 405
NBP2-99690AF405
Alexa Fluor 488
NBP2-99690AF488
Alexa Fluor 532
NBP2-99690AF532
Alexa Fluor 594
NBP2-99690AF594
Alexa Fluor 647
NBP2-99690AF647
Alexa Fluor 700
NBP2-99690AF700
Alexa Fluor 750
NBP2-99690AF750
Allophycocyanin
NBP2-99690APC
Biotin
NBP2-99690B
DyLight 350
NBP2-99690UV
DyLight 405
NBP2-99690V
DyLight 488
NBP2-99690G
DyLight 550
NBP2-99690R
DyLight 594
NBP2-99690DL594
DyLight 650
NBP2-99690C
DyLight 680
NBP2-99690FR
DyLight 755
NBP2-99690IR
FITC
NBP2-99690F
HRP
NBP2-99690H
Janelia Fluor 525
NBP2-99690JF525
Janelia Fluor 549
NBP2-99690JF549
Janelia Fluor 585
NBP2-99690JF585
Janelia Fluor 635
NBP2-99690JF635
Janelia Fluor 646
NBP2-99690JF646
Janelia Fluor 669
NBP2-99690JF669
PE
NBP2-99690PE
PerCP
NBP2-99690PCP
Unconjugated
NBP2-99690-100ul
mFluor Violet 450 SE
NBP2-99690MFV450
mFluor Violet 500 SE
NBP2-99690MFV500
mFluor Violet 610 SE
NBP2-99690MFV610
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SR-BI Antibody [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Produced in rabbits immunized with purified, recombinant Human SR-BI (Accession#: NP_005496.4; Pro33-Tyr443)
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SCARB1
Purity
Antigen and protein A Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Antigen and protein A Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for SR-BI Antibody [CoraFluor™ 1]

  • CD36 and LIMPII analogous 1
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • CD36 antigen
  • CD36L1
  • CD36L1scavenger receptor class B type 1
  • CLA1 CD36 antigen-like 1
  • CLA-1 HDLQTL6
  • CLA1
  • Collagen type I receptor, thrombospondin receptor-like 1
  • HDLQTL6
  • MGC138242
  • SCARB1
  • scavenger receptor class B type III
  • scavenger receptor class B, member 1
  • SRB1 scavenger receptor class B member 1
  • SR-B1
  • SRBI
  • SR-BI

Background

SR-BI (scavenger receptor class B member 1, SCARB1) belongs to the CD36 family and acts as a cell surface lipoprotein receptor for a variety of ligands including high density lipoprotein (HDL), phospholipids, phosphatidylserine, and lipoproteins such as lipopolysaccharide (LPS). SR-BI mediates selective uptake of HDL cholesteryl (HDL-C) ester in the liver, steroidogenic tissues, and adipose tissue and facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins. SR-BI plays a role in antigen capture and cross-presentation from bacteria, parasites, and viruses such as Hepatitis C. In endothelial cells and macrophages, SR-BI is involved in anti-inflammatory and pro-survival signaling, providing protection against atherosclerosis and clearing apoptotic cells (efferocytosis) (1, 2).

At least 5 different human splice variants have been identified with theoretical molecular weights ranging from 60.9 kDa for the canonical sequence to 45 kDa for an N-terminally truncated variant (SR-BII) (3). The extracellular domain of human SR-BI (CLA-1) shares 80%, 80%, 89%, 86% and 84% aa sequence identity with mouse, rat, porcine, rabbit, and bovine SR-BI, respectively. SR-BI is highly glycosylated and removal of N-linked glycosylation reduces lipid transport.

References

1. Linton MF, Tao H, Linton EF, Yancey PG. (2017) SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol Metab. 28(6):461-472. PMID: 28259375

2. Hoekstra M, Sorci-Thomas M. (2017) Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor. Curr Opin Lipidol. 28(3):255-260. PMID: 28301373

3. Shen WJ, Asthana S, Kraemer FB, Azhar S. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SR-BI Antibody
[CoraFluor™ 1]
NBP2-99690CL1
SR-BI Antibody [CoraFluor™ 1]
Species: Hu
Applications: WB, ICC/IF, IP

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SCARB1