LIMPII/SR-B2 Antibody

LIMP II (lysosome membrane protein 2; also called LGP85, SCARB2, CD36 antigen-like 2/CD36L2) is a member of the scavenger receptor class B member 2 family, ubiquitously expressed in higher organisms as a major lysosomal and endosomal membrane protein. LIMP II localize primarily to late endosomes/lysosomes as type III transmembrane protein, which traverses the membrane twice with the uncleaved signal peptide and a hydrophobic region near to the COOH-terminus, followed by twenty-amino acid long cytoplasmic tail of which a large portion located in lysosomal lumenal side possess 10-11 N-glycosylation sites. LIMP II acts as a lysosomal receptor for glucosylceramidase (GBA) targeting and it plays a key role in regulating the biogenesis of the endosomal/lysosomal compartments (ELCs). LIMP II serves as one of the major components of the molecular machinery required for intercompartmental membrane trafficking along the endocytic pathway rather than solely serving as a structural constituent of late endosomes and lysosomes. LIMP II deficiency has been found to result in the development of an obstruction of ureteric pelvic junction, deafness and peripheral neuropathy.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Canine.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC, IHC-P, WB.

Showing Publications 1 - 10 of 24. Show All 24 Publications. Collapse Publications.

Publications using NB400-129	Applications	Species
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA et al. Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons Elife 2023-09-11 [PMID: 37695731] (ICC/IF)	ICC/IF
Jorge-Oliva M, Smits JFM, Wiersma VI et al. Granulovacuolar degeneration bodies are independently induced by tau and alpha -synuclein pathology Alzheimer's research & therapy 2022-12-14 [PMID: 36517915] (ICC/IF, IHC-P, Human) Details: Dilution used for IHC-P 1:300, for ICC/IF	ICC/IF, IHC-P	Human
Gletten RB, Cantrell LS, Bhattacharya S, Schey KL Lens Aquaporin-5 Inserts Into Bovine Fiber Cell Plasma Membranes Via Unconventional Protein Secretion Investigative ophthalmology & visual science 2022-07-08 [PMID: 35816045]
Lee JH, Yang DS, Goulbourne CN et al. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A beta in neurons, yielding senile plaques Nature neuroscience 2022-06-01 [PMID: 35654956] (ICC/IF, Mouse)	ICC/IF	Mouse
Bertolin J, SAnchez V, Ribera A et al. Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy Nature communications 2021-09-09 [PMID: 34504088] (IHC-P, Rat)	IHC-P	Rat
van der Lienden M, Aten J, Marques A et al. GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice International Journal of Molecular Sciences 2021-03-03 [PMID: 33802460] (IHC-P, Mouse)	IHC-P	Mouse
Lee JH, Wolfe DM, Darji S et al. Beta 2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-8 J. Mol. Biol. 2020-02-24 [PMID: 32105735]
Wiersma VI, van Ziel AM, Vazquez-Sanchez S, et al. Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology Acta Neuropathol. 2019-12-01 [PMID: 31456031] (IF/IHC, Mouse)	IF/IHC	Mouse
Malla SR, Krueger B, Wartmann T et al. Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice Cell. Mol. Life Sci. 2019-07-30 [PMID: 31363815] (Mouse)		Mouse
Sun L, Tijsma A, Mirabelli C et al. Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence Emerg Microbes Infect 2019-07-25 [PMID: 31339457] (IHC-P, Mouse)	IHC-P	Mouse
Wilden AR, Molina JA, Feuerborn M et al. Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition. Biochim. Biophys. Acta 2018-09-01 [PMID: 29966622] (ICC/IF, Human)	ICC/IF	Human
Truschel ST, Clayton DR, Beckel JM et al. Age-related endolysosome dysfunction in the rat urothelium PLoS ONE 2018-06-08 [PMID: 29883476] (ICC/IF, Rat)	ICC/IF	Rat
Kondo H, Maksimova N, Otomo T et al. Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms. Hum. Mol. Genet. 2016-12-23 [PMID: 28013294] (Human)		Human
Mareninova OA, Sendler M, Malla SR et al. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cell Mol Gastroenterol Hepatol 2015-11-01 [PMID: 26693174] (Mouse)		Mouse
Gurda BL, De Guilhem De Lataillade A, Bell P et al. Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. Mol Ther 2016-02-01 [PMID: 26447927]
Ikari A, Tonegawa C, Sanada A et al. Tight Junctional Localization of Claudin-16 is Regulated by Syntaxin 8 in Renal Tubular Epithelial Cells. J. Biol. Chem. 2014-03-21 [PMID: 24659781] (ICC/IF, Canine)	ICC/IF	Canine
Fruhwurth S, Pavelka M, Bittman R et al. High-density lipoprotein endocytosis in endothelial cells. World J Biol Chem 2013-11-26 [PMID: 24340136] (ICC/IF, Human)	ICC/IF	Human
Gaspar P, Kallemeijn WW, Strijland A et al. Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. J. Lipid Res. 2014-01-01 [PMID: 24212238] (WB, Human)	WB	Human
Haurigot V, Marco S, Ribera A et al. Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy. J Clin Invest 2013-07-01 [PMID: 23863627] (IHC-P, Mouse)	IHC-P	Mouse
Lee D, Desmond MJ, fraser SA et al. Expression of the Transmembrane Lysosomal Protein SCARB2/Limp-2 in Renin Secretory Granules Controls Renin Release. Nephron Exp Nephrol 2013-04-26 [PMID: 23635510]
Gleich K, Desmond MJ, Lee D et al. Abnormal Processing of Autophagosomes in Transformed B Lymphocytes from SCARB2-Deficient Subjects. Biores Open Access 2013-02-01 [PMID: 23515316] (WB, Human)	WB	Human
Balreira A, Gaspar P, Caiola D et al. A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. Hum Mol Genet;17(14):2238-43. 2008-07-15 [PMID: 18424452] (WB, Human)	WB	Human
López-Begines S, Lavado-Roldán Á, Mesa-Cruz C et al. Neuronal lipofuscinosis caused by Kufs disease/CLN4DNAJC5mutations but not by a CSP?/DNAJC5 deficiency bioRxiv 2023-05-11 (IHC, Mouse)	IHC	Mouse
van der Lienden MJC, Aten J, Boot R, van Eijk M Glucocerebrosidase in cultured cells: extreme sensitivity for medium conditions Thesis 2022-01-01 (ICC/IF)	ICC/IF
Show All 24 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	Simple Western	Human and Rat	09/03/2018	View Summary Application Simple Western Sample Tested B103 lysate,SVG-A lysate Species Human and Rat Lot B-6

Array NB400-129

• LIMPII/SR-B2 Antibodies
• LIMPII/SR-B2 Lysate
• LIMPII/SR-B2 Proteins
• LIMPII/SR-B2 Proteins and Enzymes