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SR-BI Antibody (185-1G2 (B467)) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IP, B/N
Clone
185-1G2 (B467)
Clonality
Monoclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-12073AF350
Alexa Fluor 405
NBP3-12073AF405
Alexa Fluor 488
NBP3-12073AF488
Alexa Fluor 532
NBP3-12073AF532
Alexa Fluor 594
NBP3-12073AF594
Alexa Fluor 647
NBP3-12073AF647
Alexa Fluor 700
NBP3-12073AF700
Alexa Fluor 750
NBP3-12073AF750
Allophycocyanin
NBP3-12073APC
Biotin
NBP3-12073B
DyLight 350
NBP3-12073UV
DyLight 405
NBP3-12073V
DyLight 488
NBP3-12073G
DyLight 550
NBP3-12073R
DyLight 594
NBP3-12073DL594
DyLight 650
NBP3-12073C
DyLight 680
NBP3-12073FR
DyLight 755
NBP3-12073IR
FITC
NBP3-12073F
HRP
NBP3-12073H
Janelia Fluor 525
NBP3-12073JF525
Janelia Fluor 549
NBP3-12073JF549
Janelia Fluor 646
NBP3-12073JF646
Janelia Fluor 669
NBP3-12073JF669
PE
NBP3-12073PE
PerCP
NBP3-12073PCP
Unconjugated
NBP3-12073-0.2mg
mFluor Violet 450 SE
NBP3-12073MFV450
mFluor Violet 500 SE
NBP3-12073MFV500
mFluor Violet 610 SE
NBP3-12073MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-12073-0.2mg
Azide and BSA Free
NBP3-12073-0.2mg
Azide and BSA Free
NBP3-12073-0.025mg
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SR-BI Antibody (185-1G2 (B467)) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was raised by immunizing mice with stimulated human leukocytes.
Specificity
This antibody is specific against SR-BI. The antibody recognises an epitope between amino acids 155 - 183. SR-BI is a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. It acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry as well as mediates uptake of M. fortuitum, E. coli and S. aureus.
Isotype
IgG Kappa
Clonality
Monoclonal
Host
Rabbit
Gene
SCARB1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Block/Neutralize
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for SR-BI Antibody (185-1G2 (B467)) [CoraFluor™ 1]

  • CD36 and LIMPII analogous 1
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • CD36 antigen
  • CD36L1
  • CD36L1scavenger receptor class B type 1
  • CLA1 CD36 antigen-like 1
  • CLA-1 HDLQTL6
  • CLA1
  • Collagen type I receptor, thrombospondin receptor-like 1
  • HDLQTL6
  • MGC138242
  • SCARB1
  • scavenger receptor class B type III
  • scavenger receptor class B, member 1
  • SRB1 scavenger receptor class B member 1
  • SR-B1
  • SRBI
  • SR-BI

Background

SR-BI (scavenger receptor class B member 1, SCARB1) belongs to the CD36 family and acts as a cell surface lipoprotein receptor for a variety of ligands including high density lipoprotein (HDL), phospholipids, phosphatidylserine, and lipoproteins such as lipopolysaccharide (LPS). SR-BI mediates selective uptake of HDL cholesteryl (HDL-C) ester in the liver, steroidogenic tissues, and adipose tissue and facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins. SR-BI plays a role in antigen capture and cross-presentation from bacteria, parasites, and viruses such as Hepatitis C. In endothelial cells and macrophages, SR-BI is involved in anti-inflammatory and pro-survival signaling, providing protection against atherosclerosis and clearing apoptotic cells (efferocytosis) (1, 2).

At least 5 different human splice variants have been identified with theoretical molecular weights ranging from 60.9 kDa for the canonical sequence to 45 kDa for an N-terminally truncated variant (SR-BII) (3). The extracellular domain of human SR-BI (CLA-1) shares 80%, 80%, 89%, 86% and 84% aa sequence identity with mouse, rat, porcine, rabbit, and bovine SR-BI, respectively. SR-BI is highly glycosylated and removal of N-linked glycosylation reduces lipid transport.

References

1. Linton MF, Tao H, Linton EF, Yancey PG. (2017) SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol Metab. 28(6):461-472. PMID: 28259375

2. Hoekstra M, Sorci-Thomas M. (2017) Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor. Curr Opin Lipidol. 28(3):255-260. PMID: 28301373

3. Shen WJ, Asthana S, Kraemer FB, Azhar S. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP3-12073CL1
SR-BI Antibody (185-1G2 (B467)) [CoraFluor™ 1]
Species: Hu
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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SCARB1