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SP140 Antibody

Images

 
Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining of human small intestine shows strong nuclear positivity in lymphoid cells.
Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining of human lymph node shows strong nuclear positivity in lymphoid cells.
Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining of human pancreas shows no nuclear positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining of human placenta shows strong nuclear positivity in lymphoid cells.
Orthogonal Strategies: Immunohistochemistry-Paraffin: SP140 Antibody [NBP1-81275] - Staining in human lymph node and pancreas tissues . Corresponding SP140 RNA-seq data are presented for the same tissues.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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SP140 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: SELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLP
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SP140
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
SP140 Protein (NBP1-81275PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SP140 Antibody

  • Lymphoid-restricted homolog of Sp100
  • lymphoid-specific SP100 homolog
  • LYSP100
  • LYSP100-A
  • LYSP100-B
  • MGC126440
  • Nuclear autoantigen Sp-140
  • nuclear body protein SP140
  • SP140 nuclear body protein
  • Speckled 140 kDa

Background

SP140 is a component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SP140