IDH2 Antibody - BSA Free

Isocitrate dehydrogenase 2, also known as IDH, IDP, oxalosuccinate decarboxylase, IDPM, and mNADP-IDH, catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. IDH2 is imperative for metabolic regulation and energy production, primarily via the citric acid cycle. In addition, IDH2 has been implicated in tight interactions with the pyruvate dehydrogenase complex. IDH2 is localized in the mitochondria and is found in stems, roots and leaves. Recent research has found that mutations in IDH2 can block histone demethylation and result in an inability for cells to differentiate in gliomas (PMID: 22343901). Further studies have also linked IDH2 to both gallbladder and bile duct cancer (PMID: 22180306).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP2-22166	Applications	Species
Lin S, Yin S, Shi J et al. Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration Bioactive Materials 2022-12-01 [PMID: 35387176] (IF/IHC, Mouse)	IF/IHC	Mouse
Oyama Y, Bartman CM, Bonney S et al. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium Cell Rep 2019-08-08 [PMID: 31390562] (WB, Human)	WB	Human
Kim YR, Kim KH, Lee S et al. Expression patterns of members of the isocitrate dehydrogenase gene family in murine inner ear Biotech Histochem 2017-09-19 [PMID: 28925723] (Mouse)		Mouse
Saha SK, Gordan JD, Kleinstiver BP et al. Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in intrahepatic cholangiocarcinoma. Cancer Discov. 2016-05-26 [PMID: 27231123] (WB, Human)	WB	Human
Saha SK, Parachoniak CA, Ghanta KS et al. Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer. Nature 2014-09-04 [PMID: 25043045] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Human	01/02/2020	View Summary Application Immunocytochemistry Sample Tested 293T Species Human Lot A-1
Enlarge	5 reviewed by: Verified Customer	WB	Human	01/02/2020	View Summary Application Western Blot Sample Tested 293T Species Human Lot A-1

Array NBP2-22166

• IDH2 Antibodies
• IDH2 ELISA Kits
• IDH2 Lysate
• IDH2 Protein