Isocitrate Dehydrogenase 1/IDH1 Antibody (843219) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Isocitrate Dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to alpha ‑ketoglutarate. There are two subclasses in the IDH family, one of them utilizing NADP⁺ as the electron acceptor and the other using NAD⁺ (1). The protein encoded by this gene is the NADP⁺-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. In peroxisomes, IDH1 generates the NADPH required for intraperoxisomal reduction reactions. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‑ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from  alpha ‑ketoglutarate (2). Elevated levels of the metabolite 2HG are associated with a high risk of malignant brain tumors. Arg132 mutations of IDH1 are common in high‑grade gliomas, but not in other types of tumors (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, Immunoprecipitation.

Showing Publications 1 - 6 of 6.

Publications using MAB7049	Applications	Species
H Yang, X Zhao, J Liu, M Jin, X Liu, J Yan, X Yao, X Mao, N Li, B Liang, W Xie, K Zhang, J Zhao, L Liu, G Huang TNFalpha-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity Oncogene, 2022-11-10;0(0):. 2022-11-10 [PMID: 36352097] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Freya Q. Zhang et al. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells Cell Chemical Biology 2022-07-01 [PMID: 35429459]
Chen D, Xia S, Zhang R Et Al. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Molecular cell 7/12/2021 [PMID: 34289383]
H Yang, S Xie, B Liang, Q Tang, H Liu, D Wang, G Huang Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-Fluorouracil Journal of Cancer, 2021-06-11;12(16):4862-4872. 2021-06-11 [PMID: 34234856] (IHC, Human)	IHC	Human
Pei-Hsuan Chen, Ling Cai, Kenneth Huffman, Chendong Yang, Jiyeon Kim, Brandon Faubert et al. Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells Molecular Cell 2019-12-01 [PMID: 31564558]
D Chen, S Xia, M Wang, R Lin, Y Li, H Mao, M Aguiar, CA Famulare, AH Shih, CW Brennan, X Gao, Y Pan, S Liu, J Fan, L Jin, L Song, A Zhou, J Mukherjee, RO Pieper, A Mishra, J Peng, M Arellano, WG Blum, S Lonial, TJ Boggon, RL Levine, J Chen Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer Cancer Discov, 2019-03-12;0(0):. 2019-03-12 [PMID: 30862724] (Immunoprecipitation, Human)	Immunoprecipitation	Human

Array MAB7049

• Isocitrate Dehydrogenase 1/IDH1 Antibodies
• Isocitrate Dehydrogenase 1/IDH1 ELISA Kits
• Isocitrate Dehydrogenase 1/IDH1 Proteins
• Isocitrate Dehydrogenase 1/IDH1 Proteins and Enzyme