SP1 Antibody

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 3 applications: Chemotaxis, IP, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-20460	Applications	Species
Zhang H, Gao Y, Liu B et al. The activation of M (3) muscarinic receptor reverses liver injuryvia the Sp1/lncRNA Gm2199/miR-212 axis Acta Biochimica et Biophysica Sinica 2022-09-25 [PMID: 36111745] (WB)	WB
Zhang Z, Zhang X, Wang C Et al. Deacetylated Sp1 improves bets glycerophosphate induced calcification in vascular smooth muscle cells Experimental and Therapeutic Medicine 2021-08-10 [PMID: 34504597] (IP, Chemotaxis, WB, Rat)	IP, Chemotaxis, WB	Rat

Array NBP2-20460

• SP1 Antibodies
• SP1 Proteins