| Reactivity | HuSpecies Glossary |
| Applications | IHC |
| Clone | SOX11/3235R |
| Clonality | Monoclonal |
| Host | Rabbit |
| Conjugate | PE |
| Additional Information | Recombinant Monoclonal Antibody |
| Immunogen | Recombinant fragment (around aa300-400) of human SOX11 protein (Uniprot: P35716 ) |
| Localization | Nuclear (Cervix); Cytoplasmic (Melanoma) |
| Marker | Mantle Cell Lymphoma Marker |
| Specificity | Recognizes a protein of ~47kDa, identified as SOX11. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL. |
| Isotype | IgG |
| Clonality | Monoclonal |
| Host | Rabbit |
| Gene | SOX11 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Optimal dilution of this antibody should be experimentally determined. |
| Storage | Store at 4C in the dark. |
| Buffer | PBS |
| Preservative | 0.05% Sodium Azide |
| Purity | Protein A or G purified |
![Western Blot SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Western_Blot_5161.jpg)
![Chromatin Immunoprecipitation (ChIP) SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Chromatin_Immunoprecipitation_11224.jpg)
![Simple Western SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Simple_Western_16676.jpg)
![SOX11 Antibody (SOX11/3235R) [PE]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "SOX11 Antibody (SOX11/3235R) [PE]")
Secondary Antibodies |
Isotype Controls |
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SOX-11 seals your fate The SOX-11 transcription factor is a member of the SOX family known to be involved in embryonic development regulation and cell fate determination. The protein acts as a transcriptional regulator and appears to modulate fundamental aspects of normal e... Read full blog post. |
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
| Gene Symbol | SOX11 |
![Immunocytochemistry SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_15995.jpg)
![Western Blot SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Western_Blot_21580.jpg)
![Immunocytochemistry SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_6490.jpg)
![Immunocytochemistry SOX3 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX3_AF2569_Immunocytochemistry_9767.jpg)
![Immunocytochemistry SOX3 Antibody [Unconjugated]](https://images.novusbio.com/images/antibody/af2569_human-sox3-affinity-purified-polyclonal-ab-immunocytochemistry-2010202310230.jpg)
![Western Blot SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX15_AF4070_Western_Blot_5397.jpg)
![Immunocytochemistry SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX15_AF4070_Immunocytochemistry__Immunofluorescence_19727.jpg)
![Immunocytochemistry SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/af4070_human-sox15-affinity-purified-polyclonal-ab-immunocytochemistry-243202213427.jpg)
![Immunocytochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX10_AF2864_Immunocytochemistry__Immunofluorescence_17799.jpg)
![Immunocytochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/af2864_human-sox10-affinity-purified-polyclonal-ab-immunocytochemistry-3032021155556.jpg)
![Immunohistochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/af2864_human-sox10-affinity-purified-polyclonal-ab-immunohistochemistry-303202115544.jpg)
![Immunocytochemistry SOX21 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX21_AF3538_Immunocytochemistry__Immunofluorescence_17801.jpg)
![Immunohistochemistry SOX21 Antibody [Unconjugated]](https://images.novusbio.com/images/antibody/af3538_human-sox21-affinity-purified-polyclonal-ab-immunohistochemistry-442024145721..jpg)
![Western Blot SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Western_Blot_21133.jpg)
![Simple Western SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Simple_Western_21134.jpg)
![Immunocytochemistry SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_12364.jpg)
![Flow Cytometry: Rabbit IgG Isotype Control [PE] [NBP2-24983] - PBMCs fixed and permeabilized using the Novus intracellular staining kit and stained with 1 ug of TLR7-PE conjugate (red) or rabbit IgG-PE conjugate isotype control (NBP2-24983, green).](https://images.novusbio.com/images/Rabbit-IgG-Isotype-Control-[PE]-Flow-Cytometry-NBP2-24983-img0002.jpg "Flow Cytometry: Rabbit IgG Isotype Control [PE] [NBP2-24983] - PBMCs fixed and permeabilized using the Novus intracellular staining kit and stained with 1 ug of TLR7-PE conjugate (red) or rabbit IgG-PE conjugate isotype control (NBP2-24983, green).")