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SOCS-7/Nck/NAP4 Antibody

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Western Blot: SOCS-7/Nck/NAP4 Antibody [NBP1-06994] - Analysis of SOCS7-7/Nck/NAP4 in Daudi lysate (35ug protein in RIPA buffer) using NBP1-06994 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: SOCS-7/Nck/NAP4 Antibody [NBP1-06994] - Analysis of SOCS7-7/Nck/NAP4 in Daudi lysate (35ug protein in RIPA buffer) using NBP1-06994 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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SOCS-7/Nck/NAP4 Antibody Summary

Immunogen
Peptide with sequence C-DAGRKPKLTRTQS corresponding to internal region according to NP_055413.1.
Epitope
internal region
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SOCS7
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 1 - 3 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in lysates of Daudi (calculated MW of 63.0 kDa band according to NP_055413.1). An additional band of unknown identity was also consistently observed at 28 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-06994.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SOCS-7/Nck/NAP4 Antibody

  • NAP4
  • NAP-4
  • NAP4SOCS-7
  • Nck
  • Nck, Ash and phospholipase C binding protein
  • Nck, Ash and phospholipase C gamma-binding protein
  • NCKAP4
  • Nck-associated protein 4
  • SOCS6
  • SOCS7
  • SOCS-7
  • suppressor of cytokine signaling 7

Background

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SOCS7
Entrez
Uniprot