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SLX4 Antibody (2392A) [Unconjugated]

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SLX4 was detected in immersion fixed RAW 264.7 Mouse Monocyte/Macrophage Cell line (Mouse) and A431 Human Epithelial Carcinoma Cell Line (Human) Cells using Rabbit Anti-Human SLX4 Monoclonal Antibody (Catalog # ...read more

Product Details

Summary
Applications ICC/IF
Clone
2392A
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price

SLX4 Antibody (2392A) [Unconjugated] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Synthetic peptide within amino acids 400-500 of the Human SLX4 protein sequence
Specificity
Detects Human SLX4 immunogen sequences in Direct ELISA.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Purity Statement
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry 3-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SLX4 Antibody (2392A) [Unconjugated]

  • BTB (POZ) domain containing 12
  • BTB/POZ domain-containing protein 12
  • BTBD12
  • BTBD12structure-specific endonuclease subunit SLX4
  • FANCP
  • KIAA1784
  • KIAA1784MUS312
  • KIAA1987
  • KIAA1987FANCP
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  • SLX4

Background

SLX4 (also known as BTBD12 and FANCP) is a multidomain scaffold protein involved in DNA repair, where it has important roles in the final steps of homologous recombination. SLX4 hat interacts with three distinct nucleases: SLX1, ERCC4/XPF-ERCC1 and MUS81-EME1. Mutations in the gene are associated with the disease Fanconi anemia, a rare recessive disorder characterized by genome instability, congenital malformations, progressive bone marrow failure and predisposition to hematologic malignancies and solid tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional SLX4 Products

Blogs on SLX4.

FANCD2 (Fanconi anemia subunit D2 protein)
Fanconi anemia (FANC) is a rare, autosomal-recessive genetic disorder that is a heterogeneous cancer susceptibility condition that manifests with a wide range of symptoms such as congenital malformations, deteriorating bone marrow failure, DNA-dama...  Read full blog post.

FANCD2: A big component of the DNA repair crew
The genetic disorder known as Fanconi anemia (FANC) is a heterogeneous, autosomal-recessive cancer susceptibility condition characterized by a wide array of symptoms. These include congenital malformations, progressive bone marrow failure, DNA-damage ...  Read full blog post.

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