ATM Antibody

ATM (ataxia telangiectasia mutated kinase) is the master regulator of the DNA double-strand break (DSB) repair pathway. This ubiquitously expressed serine/threonine protein kinase belongs to the PI3K-like family of proteins and responds to DSBs caused by oxidative and other genotoxic stresses (1). In addition to regulating the DNA damage response, ATM participates in vesicle and protein transport, T-cell development, gonads/neurological function, pre-B cell allelic exclusion, cell cycle control, and acts as a tumor suppressor (2,3). Defects in ATM are associated with ataxia telangiectasia (AT), T-cell acute lymphoblastic leukemia (TALL), T-prolymphocytic leukemia (TPLL), and B-cell non-Hodgkin lymphomas (BNHL) including mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia (BCLL) (4).

The theoretical molecular weight of ATM is 350 kDa and it has 3 main domains: a FAT (focal adhesion targeting) domain (aa 1960-2566), a PI-3/PI-4 kinase catalytic domain (aa 2712-2962), and a C-terminal FAT domain (aa 3024-3056). ATM exists as a dimer or tetramer in its inactive state. Upon sensing DNA damage, the MRE11-RAD50-NBS1 (MRN) complex recruits ATM. The intricate process of ATM activation involves acetylation by KAT5/TIP60, autophosphorylation at Ser-1981, and dissociation into catalytically active monomers (5). Following activation, ATM phosphorylates multiple substrates such as p53/TP53 and Chk2 involved in DNA repair, checkpoint signaling, and the apoptosis pathway.

References

1. Paull TT. (2015) Mechanisms of ATM Activation. Annu Rev Biochem. 84:711-38. PMID: 25580527

2. Chaudhary MW and Al-Baradie RS. (2014) Ataxia-telangiectasia: future prospects. Appl Clin Genet. 7:159-167. PMID: 25258552

3. Stagni V, Cirotti C, and Barila D. (2018) Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra. Front Oncol. 8:73. PMID: 29616191

4. Gumy-Pause F, Wacker P, and Sappino AP. (2004) ATM gene and lymphoid malignancies. Leukemia. 18(2):238-42. PMID: 14628072

5. Adamowicz M. (2018) Breaking up with ATM. J Immunol Sci. 2(1):26-31. PMID: 29652413

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Canine.

We have publications tested in 8 applications: B/N, ELISA, FLOW, IB, ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 100. Show All 100 Publications. Collapse Publications.

Publications using NB100-104	Applications	Species
Urushihara Y, Hashimoto T, Fujishima Y, Hosoi Y. AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation International Journal of Molecular Sciences 2023-08-15 [PMID: 37629008] (WB)	WB
Hashimoto T, Urushihara Y, Murata Y et al. AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines Biochemical and biophysical research communications 2021-12-23 [PMID: 34973534] (WB, Human)	WB	Human
Roulston A, Zimmermann M, Papp R et al. RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors Molecular Cancer Therapeutics 2022-02-01 [PMID: 34911817] (B/N, WB)	B/N, WB
Sato H, Singer RH Cellular variability of nonsense-mediated mRNA decay Nature communications 2021-12-10 [PMID: 34893608] (ICC/IF, Human)	ICC/IF	Human
Nishiyama Y, Morita A, Tatsuta S Et al. Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome Genes 2021-09-26 [PMID: 34680909] (WB, Human)	WB	Human
Chakraborty P, Hiom K DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination Nature communications 2021-07-05 [PMID: 34226554] (WB)	WB
Gupta M, Liu X, Teraoka SN et al. Genes affecting ionizing radiation survival identified through combined exome sequencing and functional screening Human mutation 2021-06-21 [PMID: 34153142]
Celeste E Suart, Alma M Perez, Ismael Al-Ramahi, Tamara Maiuri, Juan Botas, Ray Truant Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase. Human molecular genetics 2022-03-28 [PMID: 33772540]
Zhang JQJ, Saravanabavan S, Chandra AN et al. Up-regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease The American journal of pathology 2021-02-04 [PMID: 33549515]
Chakravarti D, Hu B, Mao X et al. Telomere dysfunction activates YAP1 to drive tissue inflammation Nat Commun 2020-09-21 [PMID: 32958778] (WB, Mouse)	WB	Mouse
Habib R, Kim R, Neitzel H et al. Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome Aging (Albany NY) 2020-06-22 [PMID: 32564008]
Morita A, Aoshima K, Gulay KCM et al. High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines Res. Vet. Sci. 2019-10-17 [PMID: 31648115] (WB, Human, Canine)	WB	Human, Canine
Pugliese GM, Salaris F, Palermo V et al. Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes Dis Model Mech 2019-09-12 [PMID: 31515241] (WB, Human)	WB	Human
Karki A, Putra J, Kim SS et al. MDM4 expression in fibrolamellar hepatocellular carcinoma Oncol. Rep. 2019-07-18 [PMID: 31322272] (WB, IF/IHC, Human)	WB, IF/IHC	Human
Yin Y, Xu L, Chang Y et al. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol. Cancer 2019-01-18 [PMID: 30657058] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Dworak N, Makosa D, Chatterjee M et al. A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling Aging Cell 2018-12-19 [PMID: 30565836] (ICC/IF, Human)	ICC/IF	Human
Xu L, Ma E et al. ATM deficiency promotes progression of CRPC by enhancing Warburg effect. Endocr Relat Cancer 2019-01-01 [PMID: 30400006] (WB, Human)	WB	Human
Hashimoto T, Murata Y, Urushihara Y et al. Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways. Biochem. Biophys. Res. Commun. 2018-09-15 [PMID: 30224064] (WB, Human)	WB	Human
Gu X, Qi Y, Feng Z et al. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol. Lett. 2018-04-13 [PMID: 29660402] (WB)	WB
Murata Y, Hashimoto T, Urushihara Y et al. Knockdown of AMPKa decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217. Biochem. Biophys. Res. Commun. 2017-12-25 [PMID: 29284117] (WB, Human)	WB	Human
Wang Z, He Y, Deng W et al. Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice. Oncogene. 2018-01-04 [PMID: 28869597] (WB, Mouse)	WB	Mouse
Wu PK, Wang JY, Chen CF et al. Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. Stem Cells Transl Med 2017-06-01 [PMID: 28544661] (WB, Human)	WB	Human
Li Z, Li J, Kong Y et al. Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. Cancer Res. 2017-05-16 [PMID: 28512243] (IB, Human)	IB	Human
Qi Y, Qiu Q, Gu X et al. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts Sci Rep. 2016-04-19 [PMID: 27089984] (ICC/IF, Human) Details: The role of ATM and its influence in spermidine-induced mitophagy is investigated in human ATM-proficient and ATM-deficient cells.	ICC/IF	Human
Frum RA, Love IM, Damle PK et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol. Cancer Res. 2016-05-01 [PMID: 26965143] (FLOW, ICC/IF, Human)	FLOW, ICC/IF	Human
Nagy Z, Kalousi A, Furst A et al. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet 2016-02-01 [PMID: 26845027] (WB)	WB
Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem. Biophys. Res. Commun. 2015-11-13 [PMID: 26585486] (WB, Human)	WB	Human
Parplys AC, Zhao W, Sharma N et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015-08-31 [PMID: 26323318] (WB, Human)	WB	Human
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity. Nakamura K, Fike F, Haghayegh S Mol Genet Genomic Med 2014-02-02 [PMID: 25077176] (WB, Human)	WB	Human
Silva Barbara Alcaraz, Stambaugh Jessica R, Yokomori Kyoko et al. DNA damage to a single chromosome end delays anaphase onset. J Biol Chem. 2014-08-15 [PMID: 24982423]
Morita A, Tanimoto K, Murakami T et al. Mitochondria Are Required for ATM Activation by Extranuclear Oxidative Stress in Cultured Human Hepatoblastoma Cell Line Hep G2 Cells Biochem Biophys Res Commun. 2014-01-24 [PMID: 24406161] (WB, Human) Details: The role of ATM in response to mitochondrial oxidative stress in human cells is explored.	WB	Human
Yoon JY, Ishdorj G, Graham BA, Gibson SB. Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells. Apoptosis 2014-01-01 [PMID: 24057147] (WB, Human)	WB	Human
Gautam D, Bridge E. The Kinase Activity of Ataxia-Telangiectasia Mutated Interferes With Adenovirus E4 Mutant DNA Replication J Virol. 2013-08-01 [PMID: 23740981] (WB, Human) Details: The role of ATM and ATR kinases in MRN-dependent E4 mutant phenotypes is investigated.	WB	Human
Brinley AA, Theriot CA, Nelman-Gonzalez M et al. Characterization of Epstein?Barr virus reactivation in a modeled spaceflight system J Cell Biochem 2012-09-18 [PMID: 22991253] (FLOW, Human)	FLOW	Human
Nguyen CL, Possemato R, Bauerlein EL et al. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts Mol Cell Biol 2012-10-01 [PMID: 22851694] (WB, Human)	WB	Human
Jacquemin V, Rieunier G, Jacob S, Bellanger D, d'Enghien CD, Lauge A, Stoppa-Lyonnet D, Stern MH. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. Eur J Hum Genet. 2012-03-01 [PMID: 22071889] (ICC/IF, Human)	ICC/IF	Human
Rankin AM, Sarkar S, Faller DV et al. Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. J Cell Physiol 2012-06-01 [PMID: 21898405] (WB, Human)	WB	Human
Yang YN, Chou KM, Pan W et al. Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036 Cancer Lett 2011-10-01 [PMID: 21684680] (WB, Human)	WB	Human
Du L, Kayali R, Bertoni C et al. Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum Hum Mol Genet 2011-08-15 [PMID: 21576124] (WB, Human)	WB	Human
Dixon BP, Henry J, Siroky B et al. Cell cycle control and DNA damage response of conditionally immortalized urothelial cells PLoS One 2011-01-28 [PMID: 21305048] (WB, Mouse)	WB	Mouse
Wang SC, Wu CC, Wei YY, Hong JH, Chiang CS. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. Int J Radiat Biol;87(4):432-42. 2011-04-01 [PMID: 21204616] (FLOW, Human)	FLOW	Human
Xie P, Li L, Xing G et al. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Biochem Biophys Res Commun. 2010-12-02 [PMID: 21130744] (WB, Human)	WB	Human
Lee SY, Amsden JJ, Boriskina SV et al. Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles. Proc Natl Acad Sci U S A 2010-07-06 [PMID: 20566892] (ICC/IF)	ICC/IF
Karimi-Busheri F, Rasouli-Nia A, Mackey JR, Weinfeld M. Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res 2010-01-01 [PMID: 20525204] (IF/IHC, Human)	IF/IHC	Human
Macurek L, Lindqvist A, Voets O et al. Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene 2010-04-15 [PMID: 20101220] (Human)		Human
Hu H, Du L, Nagabayashi G et al. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci USA 2010-01-01 [PMID: 20080624] (ELISA, WB, Human)	ELISA, WB	Human
Cerqueira A, Santamaria D, Martinez-Pastor B et al. Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol 2009-12-01 [PMID: 19995934] (WB, Mouse)	WB	Mouse
Cuadrado M, Gutierrez-Martinez P, Swat A et al. p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage. Cancer Res;69(22):8726-32. 2009-11-15 [PMID: 19843869] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Arakawa R, Tsujita M, Iwamoto N et al. Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis exhibits antiatherogenesis. J Lipid Res :M900122-JLR900200. 2009-01-01 [PMID: 19458386]
Shao L, Fujii H, Colmegna I et al. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med;206(6):1435-1449. 2009-01-01 [PMID: 19451263] (WB, Human)	WB	Human
Tian C, Xing G, Xie P et al. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 2009-05-01 [PMID: 19377469] (WB, Human)	WB	Human
Liang H, Russell RS, Yonkers NL et al. Differential Effects of Hepatitis C Virus JFH1 on Human Myeloid Plasmacytoid Dendritic Cells. J Virol;83(11):5693-5707. 2009-01-01 [PMID: 19297478]
Kang TH, Reardon JT, Kemp M et al. Circadian oscillation of nucleotide excision repair in mammalian brain. Proc Natl Acad Sci U S A 2009-02-01 [PMID: 19164551] (WB, Mouse)	WB	Mouse
Nahas SA, Butch AW, Du L et al. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem 2009-03-01 [PMID: 19147735] (ELISA, WB, Human)	ELISA, WB	Human
Gruhne B, Sompallae R, Marescotti D et al. The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc Natl Acad Sci U S A;106(7):2313-2318. 2009-01-01 [PMID: 19139406] (ICC/IF, Human)	ICC/IF	Human
Vissinga CS, Yeo TC, Warren S et al. Nuclear Export of NBN Is Required for Normal Cellular Responses to Radiation. Mol Cell Biol;29(4):1000-1006. 2009-01-01 [PMID: 19075003] (WB, Mouse)	WB	Mouse
Mordes DA, Glick GG, Zhao R et al. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev;22(11):1478-89. 2008-06-01 [PMID: 18519640] (WB, Human)	WB	Human
Liu X, Matsuda A, Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther 2008-01-01 [PMID: 18202016] (WB, Human)	WB	Human
Murga, M, I Jaco et al. Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol;178(7):1101-8. 2007-09-24 [PMID: 17893239] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Yanagawa, T et al. Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Activities by the Poly(ADP-Ribose) Polymerase Family-14. Cancer Research 67: 8682-8689. 2007-01-01 [PMID: 17875708]
Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation;116(12):1404-12. 2007-09-18 [PMID: 17724261]
Choi, J et al. Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. 104(33): 13301-13306. 2007-01-01 [PMID: 17686975] (WB, Human)	WB	Human
Ambrose, M, J V Goldstine et al. Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells. Hum Mol Genet;16(18):2154-64. 2007-09-15 [PMID: 17606465] (WB, Human)	WB	Human
Olson E, Nievera CJ, Liu E et al. The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol 2007-09-01 [PMID: 17591703]
Kennedy RD, Chen CC, Stuckert P et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest 2007-05-01 [PMID: 17431503] (WB)	WB
Chu, PC et al. Silencing of p29 Affects DNA Damage Responses with UV Irradiation. Cancer Res. 66: 8484-8491. 2006-01-01 [PMID: 16951160] (WB, Human)	WB	Human
Ho, GPH et al. Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol;26(18):7005-15. 2006-09-01 [PMID: 16943440] (WB, Human)	WB	Human
Lovejoy CA et al. DDB1 maintains genome integrity through regulation of Cdt1. Mol Cell Biol 26(21):7977-90. 2006-11-01 [PMID: 16940174] (WB, Human)	WB	Human
Yang, S et al. Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. J Biol Chem;281(36):26645-54. 2006-09-08 [PMID: 16835227] (WB, IP, Mouse)	WB, IP	Mouse
Lepak A, Nett J, Lincoln L et al. Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole. Antimicrob Agents Chemother 2006-04-01 [PMID: 16569846] (WB)	WB
Cerosaletti, K et al. Active role for nibrin in the kinetics of atm activation. Mol Cell Biol;26(5):1691-9. 2006-03-01 [PMID: 16478990] (WB, Human)	WB	Human
Gaspar M, Shenk T. Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. Proc Natl Acad Sci U S A;103(8):2821-6. 2006-02-21 [PMID: 16477038] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Ariumi Y, Trono D. Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function. J Virol 2006-03-01 [PMID: 16474151] (WB)	WB
Cuadrado, M et al. ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med;203(2):297-303. 2006-02-20 [PMID: 16461339] (WB, Human)	WB	Human
Hiyama, T et al. Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res;34(3):880-92. 2006-02-02 [PMID: 16456034] (ICC/IF, Human)	ICC/IF	Human
Hovest, MG et al. Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase persistent DNA damage foci at telomerase. Mol Biol Cell 17: 1758-1767. 2006-01-01 [PMID: 16436511] (IP, Human)	IP	Human
Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 2006-04-01 [PMID: 16431910] (WB, Human)	WB	Human
Yesilaltay, A et al. Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility. Endocrinology;147(4):1577-88. 2006-04-01 [PMID: 16410302]
Harder, CJ et al. Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. J Lipid Res;47(3):492-503. 2006-03-01 [PMID: 16339112]
Zhang L, Tie Y, Tian C et al. CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal 2006-09-01 [PMID: 16325375] (WB, Human)	WB	Human
Lilley CE, Carson CT, Muotri AR et al. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci USA 2005-04-01 [PMID: 15824307] (WB, Human)	WB	Human
Out R et al. Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. J Lipid Res;46(6):1172-81. 2005-06-01 [PMID: 15772431] (WB, Mouse)	WB	Mouse
Peng Y, Woods RG, Beamish H et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005-03-01 [PMID: 15753361] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Ariumi Y, Turelli P, Masutani M, Trono D. DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J Virol 2005-03-01 [PMID: 15709017] (WB)	WB
Butch, A et al. Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates. Clin Chem;50(12):2302-8. 2004-12-01 [PMID: 15486025] (ELISA, WB, Human)	ELISA, WB	Human
Yan, T et al. CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Mol Cancer Ther;3(9):1147-57. 2004-09-01 [PMID: 15367709] (WB, Human)	WB	Human
Caporali, S et al. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. Mol Pharmacol;66(3):478-91. 2004-09-01 [PMID: 15322239] (IP, WB, Human)	IP, WB	Human
Cerosaletti K, Concannon P. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem 2004-09-01 [PMID: 15234984] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Dow GS, Koenig ML, Wolf L et al. The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains. Antimicrob Agents Chemother 2004-07-01 [PMID: 15215119] (WB)	WB
Cortez, D. Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. J Biol Chem;278(39):37139-45. 2003-09-26 [PMID: 12847089] (WB, Human)	WB	Human
Sorensen, C et al. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell;3(3):247-58. 2003-03-01 [PMID: 12676583] (IP, Human)	IP	Human
Casper, A et al. ATR regulates fragile site stability. Cell;111(6):779-89. 2002-12-13 [PMID: 12526805] (WB, Human)	WB	Human
Nagelli S CIP2A IS A CRITICAL DNA DAMAGE RESPONSE PROTEIN THAT DRIVES BASAL-LIKE BREAST CANCER Thesis 2023-01-01 (WB)	WB
Nakanishi K, Taniguchi T, Ranganathan V et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002-12-01 [PMID: 12447395] (WB, Human)	WB	Human
Stracker TH, Carson CT, Weitzman MD. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 2002-07-01 [PMID: 12124628] (WB, Human)	WB	Human
Oakley, G et al. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. Mol Biol Cell;12(5):1199-213. 2001-05-01 [PMID: 11359916] (WB, Human)	WB	Human
Vemuri MC, Schiller E, Naegele JR. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ;8(3):245-55. 2001-03-01 [PMID: 11319607] (IF/IHC, Mouse)	IF/IHC	Mouse
Scherthan H, Jerratsch M, Dhar S et al. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol 2000-10-01 [PMID: 11003672] (WB, Mouse)	WB	Mouse
Wang Y, Cortez D, Yazdi P et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000-04-01 [PMID: 10783165] (ICC/IF, IF/IHC, IP, WB, Human)	ICC/IF, IF/IHC, IP, WB	Human
Cortez, D et al. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science;286(5442):1162-6. 1999-11-05 [PMID: 10550055] (WB, IP, Human)	WB, IP	Human
Show All 100 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Barbara Alcaraz Silva	IF	Other	10/08/2014	View Summary Application Immunofluorescence Sample Tested cell Species Other Lot N1
Enlarge	4 reviewed by: Christie Brown	WB	Human	08/15/2013	View Summary Application Western Blot Sample Tested Lymphoblastoid (LCL) nuclear lysate Species Human Lot P-1

Array NB100-104

• ATM Antibodies
• ATM ELISA Kits
• ATM Proteins