The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
30 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using NBP2-27182 in the following applications:
Rat SNAIL2 (SNAI2) (89%). Mouse reactivity reported in scientific literature (PMID: 26240017)
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified
Alternate Names for Slug Antibody
MGC10182
Neural crest transcription factor Slug
Protein snail homolog 2
slug homolog, zinc finger protein (chicken)
Slug
SLUGH
SLUGH1
SLUGzinc finger protein
SNAI2
snail 2
snail homolog 2 (Drosophila)
SNAIL2
WS2D
zinc finger protein SNAI2
Background
Zinc finger transcription factor SNAIL2 (SNAI2, Slug) is found to have some functional significance in formation of axis and mesoderm in Drosophila. SNAIL2 and Twist act as negative regulators of level of Cerberus RNA, which encodes a Nodal, bone morphogenic protein (BMP) and WNT inhibitor. mRNA levels of SNAIL2 are regulated by NF-kappaB in early embryo. Partial functional redundancy between Twist, SNAIL2 and SNAIL1 may be developmentally and physiologically significant given their roles in the induction and progression of various forms of epithelial-mesenchymal transition and the metastasis of cancer cells, the regulation of apoptosis, and their ability to generate stem cell like behaviors in immortalized human epithelial cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Epithelial-Mesenchymal Transition (EMT) Markers Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a... Read full blog post.
CD63: is it pro-metastatic or anti-metastatic? CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,... Read full blog post.
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