Serpin E1/PAI-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

As a member of the Serpin superfamily of serine protease inhibitors, Serpin E1/PAI-1 is the principal inhibitor of urokinase-type plasminogen activator (uPA) and tissue-type PA (1, 2). As important regulators of extracellular matrix remodeling, uPA and PAI-1 play a major role in many processes such as angiogenesis, tumor invasion and obesity (2-4). For example, uPA and PAI-1 are the only tumor prognostic factors validated at the highest level of evidence with regard to their clinical utility in breast cancer (5). The human PAI-1 is initially synthesized as 402 amino acid precursor with a N-terminal signal peptide (6, 7). PAI-1 may exist in one of two possible conformations, designated as active or latent (8). The purified recombinant human (rh) PAI-1 is active against rhuPA. The heterogeneity at the N-terminus of the purified rhPAI-1 has been observed before for both the recombinant and native proteins (9).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 4 applications: Dot Blot, IHC-Fr, Neutralization, Western Blot.

Showing Publications 1 - 9 of 9.

Publications using AF1786	Applications	Species
GK Annarapu, D Nolfi-Done, M Reynolds, Y Wang, L Kohut, B Zuckerbrau, S Shiva Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion Redox Biology, 2021-12-05;48(0):102205. 2021-12-05 [PMID: 34891098] (Dot Blot, Human)	Dot Blot	Human
Jeny F, Bernaudin JF, Valeyre D Et al. Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis Frontiers in immunology 8/11/2021 [PMID: 34456926]
Hiroki Sakamoto, Yu-ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu et al. PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages Laboratory Investigation 3/1/2021 [PMID: 33311557]
X Li, N Niu, J Sun, Y Mou, X He, L Mei IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1, and IGFBP1 FEBS Open Bio, 2020-11-09;0(0):. 2020-11-09 [PMID: 33064893] (Neutralization, Human)	Neutralization	Human
Aysha Ferdoushi, Xiang Li, Nathan Griffin, Sam Faulkner, M. Fairuz B. Jamaluddin, Fangfang Gao et al. Schwann Cell Stimulation of Pancreatic Cancer Cells: A Proteomic Analysis Frontiers in Oncology 8/25/2020 [PMID: 32984024]
MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer Cell Rep, 2018-11-20;25(8):2177-2191.e7. 2018-11-20 [PMID: 30463014] (Western Blot, Human)	Western Blot	Human
Y Zhao, C Wang, C Wang, X Hong, J Miao, Y Liao, L Zhou, Y Liu An essential role for Wnt/?-catenin signaling in mediating hypertensive heart disease Sci Rep, 2018-06-12;8(1):8996. 2018-06-12 [PMID: 29895976] (Western Blot, Rat)	Western Blot	Rat
Misako Sato, Mitsutaka Kadota, Binwu Tang, Howard H Yang, Yu-an Yang, Mengge Shan et al. An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-beta in human breast cancer Breast Cancer Research 6/2/2014 [PMID: 24890385]
Gao S, Krogdahl A, Sorensen J, Kousted T, Dabelsteen E, Andreasen P Overexpression of protease nexin-1 mRNA and protein in oral squamous cell carcinomas. Oral Oncol, 2007-04-30;44(3):309-13. 2007-04-30 [PMID: 17468036] (IHC-Fr, Human)	IHC-Fr	Human

Array AF1786

• Serpin E1/PAI-1 Antibodies
• Serpin E1/PAI-1 Antibody Pair
• Serpin E1/PAI-1 ELISA Kits
• Serpin E1/PAI-1 Lysate
• Serpin E1/PAI-1 Proteins
• Serpin E1/PAI-1 ELISAs
• Serpin E1/PAI-1 Proteins and Enzyme