Name: Serpin A3N Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF4709
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	WB, IP
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse Serpin A3N Phe21-Lys418 Accession # Q91WP6
Specificity	Detects mouse Serpin A3N in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse (rm) Serpin A1, recombinant human Serpin A3 and rmSerpin A5 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	Serpina3n
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF4709	Applications	Species
Mittra, N;He, S;Bao, H;Bhattacharjee, A;Dodds, SG;Dupree, JL;Han, X; Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation bioRxiv : the preprint server for biology 2024-11-14 [PMID: 39605561] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
Aubert, A;Liu, A;Kao, M;Goeres, J;Richardson, KC;Nierves, L;Jung, K;Nabai, L;Zhao, H;Orend, G;Krawetz, R;Lange, PF;Younger, A;Chan, J;Granville, DJ; Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis JCI insight 2024-10-17 [PMID: 39475853] (Western Blot, Human)	Western Blot	Human
Koupourtidou, C;Schwarz, V;Aliee, H;Frerich, S;Fischer-Sternjak, J;Bocchi, R;Simon-Ebert, T;Bai, X;Sirko, S;Kirchhoff, F;Dichgans, M;Götz, M;Theis, FJ;Ninkovic, J; Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex Nature communications 2024-04-03 [PMID: 38570482] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
J Hou, Y Zhou, Z Cai, M Terekhova, A Swain, PS Andhey, RM Guimaraes, A Ulezko Ant, T Qiu, S Sviben, G Strout, JAJ Fitzpatric, Y Chen, S Gilfillan, DH Kim, SJ Van Dyken, MN Artyomov, M Colonna Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination Cell Reports, 2023-03-21;42(4):112293. 2023-03-21 [PMID: 36952346] (IHC, Mouse)	IHC	Mouse
Y Zhou, M Tada, Z Cai, PS Andhey, A Swain, KR Miller, S Gilfillan, MN Artyomov, M Takao, A Kakita, M Colonna Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia Nature Immunology, 2023-01-19;0(0):. 2023-01-19 [PMID: 36658241] (IHC, Mouse)	IHC	Mouse
Melanie Tran, Md Golam Mostofa, Michael Picard, Jianguo Wu, Li Wang, Dong-Ju Shin SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice Journal of Endocrinology 2023-03-01 [PMID: 36625462]
NB McNamara, DAD Munro, N Bestard-Cu, A Uyeda, JFJ Bogie, A Hoffmann, RK Holloway, I Molina-Gon, KE Askew, S Mitchell, W Mungall, M Dodds, C Dittmayer, J Moss, J Rose, S Szymkowiak, L Amann, BW McColl, M Prinz, TL Spires-Jon, W Stenzel, K Horsburgh, JJA Hendriks, C Pridans, R Muramatsu, A Williams, J Priller, VE Miron Microglia regulate central nervous system myelin growth and integrity Nature, 2022-12-14;0(0):. 2022-12-14 [PMID: 36517604] (IHC, Mouse)	IHC	Mouse
NB McNamara, DAD Munro, N Bestard-Cu, A Uyeda, JFJ Bogie, A Hoffmann, RK Holloway, I Molina-Gon, KE Askew, S Mitchell, W Mungall, M Dodds, C Dittmayer, J Moss, J Rose, S Szymkowiak, L Amann, BW McColl, M Prinz, TL Spires-Jon, W Stenzel, K Horsburgh, JJA Hendriks, C Pridans, R Muramatsu, A Williams, J Priller, VE Miron Microglia regulate central nervous system myelin growth and integrity Nature, 2022;0(0):. 2022 [PMID: 36517604] (IHC, Mouse)	IHC	Mouse
J Wagner, K Degenhardt, M Veit, N Louros, K Konstantou, A Skodras, K Wild, P Liu, U Obermüller, V Bansal, A Dalmia, LM Häsler, M Lambert, M De Vleesch, HA Davies, J Madine, D Kronenberg, R Feederle, D Del Turco, KPR Nilsson, T Lashley, T Deller, M Gearing, LC Walker, P Heutink, F Rousseau, J Schymkowit, M Jucker, JJ Neher Medin co-aggregates with vascular amyloid-beta in Alzheimer's disease Nature, 2022-11-16;0(0):. 2022-11-16 [PMID: 36385530] (IHC, Mouse)	IHC	Mouse
T Kaya, N Mattugini, L Liu, H Ji, L Cantuti-Ca, J Wu, M Schifferer, J Groh, R Martini, S Besson-Gir, S Kaji, A Liesz, O Gokce, M Simons CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging Nature Neuroscience, 2022-10-24;25(11):1446-1457. 2022-10-24 [PMID: 36280798] (IHC, Mouse)	IHC	Mouse
Y Shen, W Yang, X Xiong, X Li, Z Xiao, J Yu, F Liu, S Gui, X Xie, F Lv, L Zhao, L Hu, A Manaenko, P Xie, Q Li Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage Oxidative Medicine and Cellular Longevity, 2021-12-14;2021(0):2510847. 2021-12-14 [PMID: 36226158] (Western Blot, Mouse)	Western Blot	Mouse
M Kenigsbuch, P Bost, S Halevi, Y Chang, S Chen, Q Ma, R Hajbi, B Schwikowsk, B Bodenmille, H Fu, M Schwartz, I Amit A shared disease-associated oligodendrocyte signature among multiple CNS pathologies Nature Neuroscience, 2022-06-27;0(0):. 2022-06-27 [PMID: 35760863] (IHC, Mouse)	IHC	Mouse
Sivaprakasam R. Saroja, Abhijeet Sharma, Patrick R. Hof, Ana C. Pereira Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease Alzheimer's & Dementia 2022-09-01 [PMID: 34873815]
S Qiu, JP Palavicini, J Wang, NS Gonzalez, S He, E Dustin, C Zou, L Ding, A Bhattachar, CE Van Skike, V Galvan, JL Dupree, X Han Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment Molecular Neurodegeneration, 2021-09-15;16(1):64. 2021-09-15 [PMID: 34526055] (IHC, Mouse)	IHC	Mouse
Hai-Tao Jiang, Rui Deng, Yan Deng, Mao Nie, Yi-Xuan Deng, Hong-Hong Luo et al. The role of Serpina3n in the reversal effect of ATRA on dexamethasone-inhibited osteogenic differentiation in mesenchymal stem cells Stem Cell Research & Therapy 2021-12-01 [PMID: 34001245]
YT Ho, T Shimbo, E Wijaya, T Kitayama, S Takaki, K Ikegami, K Miyashita, Y Ouchi, E Takaki, R Yamamoto, Y Kaneda, K Tamai Longitudinal single cell transcriptomics reveals a role for Serpina3n-mediated resolution of inflammation in a mouse colitis model Cellular and Molecular Gastroenterology and Hepatology, 2021-04-13;0(0):. 2021-04-13 [PMID: 33862275] (IHC, Immunoprecipitation, Western Blot, Mouse)	IHC, Immunoprecipitation, Western Blot	Mouse
MM Akbor, N Kurosawa, H Nakayama, A Nakatani, K Tomobe, Y Chiba, M Ueno, M Tanaka, Y Nomura, M Isobe Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta PLoS ONE, 2021-03-04;16(3):e0248027. 2021-03-04 [PMID: 33662018] (IHC, Mouse)	IHC	Mouse
Gregory J. Heller, Michael S. Marshall, Yazan Issa, Jeffrey N. Marshall, Duc Nguyen, Emily Rue et al. Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease Molecular Therapy 2021-05-01 [PMID: 33508430]
Nicolás Fissolo, Clara Matute-Blanch, Mohamoud Osman, Carme Costa, Rucsanda Pinteac, Berta Miró et al. CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS Neurology - Neuroimmunology Neuroinflammation 2021-03-01 [PMID: 33436375]
E Staurenghi, V Cerrato, P Gamba, G Testa, S Giannelli, V Leoni, C Caccia, A Buffo, W Noble, BG Perez-Niev, G Leonarduzz Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2 Redox Biology, 2020-12-17;39(0):101837. 2020-12-17 [PMID: 33360775] (Western Blot, Mouse)	Western Blot	Mouse
IS Massart, G Paulissen, A Loumaye, P Lause, SA Pötgens, MM Thibaut, E Balan, L Deldicque, A Atfi, E Louis, D Gruson, LB Bindels, MA Meuwis, JP Thissen Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Cancers (Basel), 2020-10-31;12(11):. 2020-10-31 [PMID: 33142864] (Western Blot, Mouse)	Western Blot	Mouse
SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi Nat Commun, 2020-08-14;11(1):4102. 2020-08-14 [PMID: 32796823] (IHC, Mouse)	IHC	Mouse
JJ Hulmi, F Penna, N Pöllänen, TA Nissinen, J Hentilä, L Euro, JH Lautaoja, R Ballarò, R Soliymani, M Baumann, O Ritvos, E Pirinen, M Lalowski Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia - the effects of blocking myostatin and activins Mol Metab, 2020-06-26;0(0):101046. 2020-06-26 [PMID: 32599075] (Western Blot, Mouse)	Western Blot	Mouse
N Habib, C McCabe, S Medina, M Varshavsky, D Kitsberg, R Dvir-Szter, G Green, D Dionne, L Nguyen, JL Marshall, F Chen, F Zhang, T Kaplan, A Regev, M Schwartz Disease-associated astrocytes in Alzheimer's disease and aging Nat. Neurosci., 2020-04-27;23(6):701-706. 2020-04-27 [PMID: 32341542] (IHC, Mouse)	IHC	Mouse
Na Zhao, Yingxue Ren, Yu Yamazaki, Wenhui Qiao, Fuyao Li, Lindsey M. Felton et al. Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways Neuron 2020-06-01 [PMID: 32199103]
DA Lipski, V Foucart, R Dewispelae, LE Caspers, M Defrance, C Bruyns, F Willermain Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach BMC Ophthalmol, 2020-03-17;20(1):106. 2020-03-17 [PMID: 32183784] (IF, Mouse)	IF	Mouse
Y Zhou, WM Song, PS Andhey, A Swain, T Levy, KR Miller, PL Poliani, M Cominelli, S Grover, S Gilfillan, M Cella, TK Ulland, K Zaitsev, A Miyashita, T Ikeuchi, M Sainouchi, A Kakita, DA Bennett, JA Schneider, MR Nichols, SA Beausoleil, JD Ulrich, DM Holtzman, MN Artyomov, M Colonna Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease Nat. Med., 2020-01-13;26(1):131-142. 2020-01-13 [PMID: 31932797] (IHC, Mouse)	IHC	Mouse
Domenico Sergi, Fiona M. Campbell, Christine Grant, Amanda C. Morris, Eva-Maria Bachmair, Christiane Koch et al. SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice Genes & Nutrition 2018-12-01 [PMID: 30519364]
MJ Dalby, G Aviello, AW Ross, AW Walker, P Barrett, PJ Morgan Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N Sci Rep, 2018-10-23;8(1):15648. 2018-10-23 [PMID: 30353127] (IHC, Mouse)	IHC	Mouse
Marine Gueugneau, Donatienne d'Hose, Caroline Barbé, Marie de Barsy, Pascale Lause, Dominique Maiter et al. Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy Journal of Cachexia, Sarcopenia and Muscle 2018-10-01 [PMID: 29989354]
S Vanni, F Moda, M Zattoni, E Bistaffa, E De Cecco, M Rossi, G Giaccone, F Tagliavini, S Haïk, JP Deslys, G Zanusso, JW Ironside, I Ferrer, GG Kovacs, G Legname Differential overexpression of SERPINA3 in human prion diseases Sci Rep, 2017-11-15;7(1):15637. 2017-11-15 [PMID: 29142239] (Western Blot, Mouse)	Western Blot	Mouse
Vicuna L, Strochlic D, Latremoliere A, Bali K, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin R, Njoo C, Gehrig S, Mall M, Arnold B, Devor M, Woolf C, Liberles S, Costigan M, Kuner R The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med, 2015-04-27;21(5):518-23. 2015-04-27 [PMID: 25915831] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
I Hsu, L G Parkinson, Y Shen, A Toro, T Brown, H Zhao et al. Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing Cell Death & Disease 2014-10-09 [PMID: 25299783]
Williams , Lynda M, Campbell , Fiona M, Drew , Janice E, Koch , Christia, Hoggard , Nigel, Rees , William, Kamolrat , Torkamol, Thi Ngo , Ha, Steffensen , Inger-Li, Gray , Stuart R, Tups , Alexande The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. PLoS ONE, 2014-08-29;9(8):e106159. 2014-08-29 [PMID: 25170916] (Western Blot, Mouse)	Western Blot	Mouse
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Serpin A3N Antibody [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free AF4709-SP

Gene Symbol	Serpina3n
Uniprot	Q91WP6(Mouse)