SERCA2 ATPase Antibody (IID8) - BSA Free

ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 8 of 8.

Publications using NB300-529	Applications	Species
Tagliari AP, Taramasso M. The Heart in the Transcatheter Intervention Era: Where Are We? Journal of clinical medicine 2022-09-01 [PMID: 36079102]
Combot Y, Salo VT, Chadeuf G et al. Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes Cell reports 2022-01-11 [PMID: 35021082]
Sun A, Wei J, Childress C et al. The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy Autophagy. 2017-01-12 [PMID: 28085563] (ICC/IF, Human)	ICC/IF	Human
Leatherbury L, Yu Q, Chatterjee B et al. A novel mouse model of X-linked cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2008-04-18 [PMID: 18424640]
Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hiesberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ. Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest 114(10):1433-43. 2004-11-01 [PMID: 15545994]
Kjellgren D, Ryan M, Ohlendieck K et al. Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles. Invest Ophthalmol Vis Sci. 2003-12-01 [PMID: 14638697]
Adachi T, Matsui R, Xu S et al. Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-ATPase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res 90(10):1114-21. 2002-05-31 [PMID: 12039802]
Molnar E, Seidler NW, Jona I, Martonosi AN. The binding of monoclonal and polyclonal antibodies to the Ca2(+)-ATPase of sarcoplasmic reticulum: effects on interactions between ATPase molecules. Biochim Biophys Acta 1023(2):147-67. 1990-04-13 [PMID: 1691656]

Array NB300-529

• SERCA2 ATPase Antibodies
• SERCA2 ATPase ELISA Kits
• SERCA2 ATPase Proteins