Phospholamban Antibody

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Porcine.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-19807	Applications	Species
Cuello F, Knaust AE, Saleem U et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation EMBO molecular medicine 2021-05-16 [PMID: 33998164] (ICC/IF, Human)	ICC/IF	Human
Rudolph T, Mayorga E, Roths M et al. The effect of Mitoquinol (MitoQ) on heat stressed skeletal muscle from pigs, and a potential confounding effect of biological sex Journal of Thermal Biology 2021-04-01 [PMID: 33863453] (WB, Porcine)	WB	Porcine
Stathopoulou K, Schobesberger S, Bork NI et al. Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes Cell. Signal. 2019-07-22 [PMID: 31344438] (WB, Rat, Mouse)	WB	Rat, Mouse

Array NBP2-19807

• Phospholamban Antibodies
• Phospholamban Proteins