Name: FoxC2 Antibody
Brand: Novus Biologicals
SKU: AF6989
Price: 469 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	IHC
Clonality	Polyclonal
Host	Sheep
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	E. coli-derived recombinant mouse FoxC2 Ala412-Tyr494 Accession # Q61850
Specificity	Detects mouse FoxC2 in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) FoxC2 is observed and less than 3% cross-reactivity with rhFoxF2 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Sheep
Gene	FOXC2
Purity	Immunogen affinity purified
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Purity	Immunogen affinity purified
Reconstitution Instructions	Sterile PBS to a final concentration of 0.2 mg/mL.

Publications using AF6989	Applications	Species
Chen, D;Wiggins, D;Sevick, EM;Davis, MJ;King, PD; An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves bioRxiv : the preprint server for biology 2023-11-23 [PMID: 38045382] (IHC, Mouse)	IHC	Mouse
Alexis Leigh Krup, Sarah A. B. Winchester, Sanjeev S. Ranade, Ayushi Agrawal, W. Patrick Devine, Tanvi Sinha et al. A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors Development 5/1/2023 [PMID: 36994838]
Wang S, Gong Y, Wang Z et al. Regulon active landscape reveals cell development and functional state changes of human primary osteoblasts in vivo Human genomics 2/15/2023 [PMID: 36793138]
P Flora, MY Li, PM Galbo, M Astorkia, D Zheng, E Ezhkova Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration PloS Genetics, 2021-12-14;17(12):e1009948. 2021-12-14 [PMID: 34905545] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Rafael S. Czepielewski, Emma C. Erlich, Emily J. Onufer, Shannon Young, Brian T. Saunders, Yong-Hyun Han et al. Ileitis-associated tertiary lymphoid organs originate at lymphatic valves and obstruct mesenteric lymph flow in response to tumor necrosis factor Immunity 12/1/2021 [PMID: 34788601]
Meritxell Sáez, Robert Blassberg, Elena Camacho-Aguilar, Eric D. Siggia, David A. Rand, James Briscoe Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions Cell Systems 1/19/2022 [PMID: 34536382]
Lindstrom NO, Sealfon R, Chen X et al. Spatial Transcriptional Mapping of the Human Nephrogenic Program Dev Cell 8/24/2021 [PMID: 34428401]
Hao Liu, Zhe Zhang, Yanan Han, Ahui Fan, Haiming Liu, Xiangyuan Zhang et al. The FENDRR/FOXC2 Axis Contributes to Multidrug Resistance in Gastric Cancer and Correlates With Poor Prognosis Frontiers in Oncology 3/22/2021 [PMID: 33869020]
Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim et al. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling Development 12/1/2020 [PMID: 33060128]
Maike Frye, Simon Stritt, Henrik Ortsäter, Magda Hernandez Vasquez, Mika Kaakinen, Andres Vicente et al. EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity eLife 9/8/2020 [PMID: 32897857]
MM Mikedis, Y Fan, PK Nicholls, T Endo, EK Jackson, SA Cobb, DG de Rooij, DC Page DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors Elife, 2020-07-20;9(0):. 2020-07-20 [PMID: 32686646] (IHC-P, Mouse)	IHC-P	Mouse
Pieter R Norden, Amélie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana V Petrova et al. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation eLife 6/8/2020 [PMID: 32510325]
Md. Riaj Mahamud, Xin Geng, Yen-Chun Ho, Boksik Cha, Yuenhee Kim, Jing Ma et al. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126 Development 11/1/2019 [PMID: 31582413]
Xianghu Qu, Kate Violette, M. K. Sewell-Loftin, Jonathan Soslow, LeShana Saint-Jean, Robert B. Hinton et al. Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling Developmental Biology 11/1/2019 [PMID: 31319059]
Tran T, Lindstrom NO, Ransick A et al. In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes Dev. Cell 7/1/2019 [PMID: 31265809]
K Nonomura, V Lukacs, DT Sweet, LM Goddard, A Kanie, T Whitwam, SS Ranade, T Fujimori, ML Kahn, A Patapoutia Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation Proc. Natl. Acad. Sci. U.S.A., 2018-11-27;0(0):. 2018-11-27 [PMID: 30482854] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kimberly E. Inman, Carlo Donato Caiaffa, Kristin R. Melton, Lisa L. Sandell, Annita Achilleos, Tsutomu Kume et al. Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion Developmental Dynamics 12/1/2018 [PMID: 30376688]
B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling Cell Rep, 2018-10-16;25(3):571-584.e5. 2018-10-16 [PMID: 30332639] (IHC, Western Blot, Human, Mouse)	IHC, Western Blot	Human, Mouse
Nils O. Lindström, Tracy Tran, Jinjin Guo, Elisabeth Rutledge, Riana K. Parvez, Matthew E. Thornton et al. Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning Journal of the American Society of Nephrology 3/1/2018 [PMID: 29449451]
A Milasan, G Jean, F Dallaire, JC Tardif, Y Merhi, M Sorci-Thom, C Martel Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice J Am Heart Assoc, 2017-09-22;6(9):. 2017-09-22 [PMID: 28939717] (IHC, Mouse)	IHC	Mouse
Oliver Lyons, Prakash Saha, Christopher Seet, Adam Kuchta, Andrew Arnold, Steven Grover et al. Human venous valve disease caused by mutations in FOXC2 and GJC2 Journal of Experimental Medicine 8/7/2017 [PMID: 28724617]
Boksik Cha Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves Genes Dev, 2016-06-16;30(12):1454-69. 2016-06-16 [PMID: 27313318] (IHC-Fr, Western Blot, Human, Mouse)	IHC-Fr, Western Blot	Human, Mouse
Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation J Clin Invest, 2016-05-23;0(0):. 5/23/2016 [PMID: 27214551]
Sweet D, Jimenez J, Chang J, Hess P, Mericko-Ishizuka P, Fu J, Xia L, Davies P, Kahn M Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest, 2015-07-27;125(8):2995-3007. 2015-07-27 [PMID: 26214523] (IHC-P, Mouse)	IHC-P	Mouse
Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest, 2014-07-25;124(9):3960-74. 2014-07-25 [PMID: 25061877] (IHC, Mouse)	IHC	Mouse
Sandrine Levet, Delphine Ciais, Galina Merdzhanova, Christine Mallet, Teresa A. Zimmers, Se-Jin Lee et al. Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation Blood 7/25/2013 [PMID: 23741013]
Show All 26 Publications. Collapse Publications.

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Catalog# & Formulation	Size	Price
Carrier Free AF6989-SP

Gene Symbol	FOXC2
Uniprot	Q61850(Mouse)