SCD-1 Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

SCD (stearoyl-CoA desaturase, or SCD1) is the terminal component of liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a range of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (de novo synthesis of monounsaturated fats from saturated fatty acids). SCD1 promoter region is bound by a wide array of transcription factors, including SREBP-1 and PPAR-alpha and the expression of SREBP-1 as well as SCD1 is upregulated by PI3K/mTOR signaling. Moreover, SCD1 transcription is hormonally upregulated by insulin and growth factors, but inhibited by estrogen and leptin. Oleate (an 18:1 fatty acid) is the major monounsaturated fatty acid of membrane phospholipids, triglycerides, cholesteryl esters, wax esters and alkyl-1,2-diacylglycerol. The ratio of unsaturated to saturated fatty acids is one of the factors influencing membrane fluidity; its alteration is important in a number of diseases, such as cancer, diabetes, obesity, and neurological, vascular and heart disease. This ratio, referred to as Desaturation Index, can be analyzed for multiple fatty acids in plasma and represents a potential biomarker of SCD inhibition.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-26393V

• SCD-1 Antibodies
• SCD-1 Lysate
• SCD-1 Proteins