RIG-I Antibody - BSA Free

RIG-I belongs to the Helicase family and contains two CARD domains, one helicase ATP-binding domain and one helicase C-terminal domain. It is involved in innate immune defense against viruses. It triggers a transduction cascade involving MAVS/IPS1 which leads to activation of NF-kappa-B, IRF3 and IRF7 inducing expression of antiviral cytokines such as INF-beta and RANTES (CCL5) during viral replication. Reports also says that TLR3 and RIG-like receptor on myeloid dendritic cells and Rig-like receptor on human Nk cells are both required for production of IFN-gamma in response to double-stranded RNA during viral infection.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP2-27419	Applications	Species
Seki E, Yoshizumi M, Tanaka R et al. Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts. Cell Biol Int. 2013-01-22 [PMID: 23377960]

Array NBP2-27419

• RIG-I Antibodies
• RIG-I Lysate
• RIG-I Protein