RIG-I Antibody - BSA Free

The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-76732	Applications	Species
Cali M. McEntee, Alyssa N. Cavalier, Thomas J. LaRocca ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes Frontiers in Molecular Neuroscience 2023-10-25 [PMID: 38035265]
Zhu J, Duan G, Wang H et al. TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPk signaling and the RLRs and TLRs on macrophages. Exp. Cell Res. 2016-05-26 [PMID: 27237091] (WB, Mouse)	WB	Mouse

Array NBP1-76732

• RIG-I Antibodies
• RIG-I Lysate
• RIG-I Protein