Recombinant Mouse Periostin/OSF-2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Periostin, also known as OSF-2, is a secreted matricellular protein with functions in extracellular matrix formation, cell migration, and inflammation (1). It is secreted as a 90 kDa monomer that can aggregate into >170 kDa higher-order multimers (2). Periostin contains an N-terminal EMI domain followed by four tandem FAS1 domains (3). Mature mouse Periostin shares 91% and 98% aa sequence identity with mouse and rat Periostin, respectively. Alternative splicing generates additional isoforms with various deletions in the C-terminal region following the FAS domains. Periostin is expressed by mesenchymal cells such as vascular smooth muscle cells, fibroblasts, osteoblasts, and odontoblasts in developing teeth (4-7). It is up-regulated in many carcinomas (2, 8). Periostin binds to Integrins alpha _v beta ₃ and alpha _v beta ₅ (2, 9), leading to enhanced cell adhesion and cell migration (2, 5, 6). It enhances Fibronectin and Collagen I production and promotes collagen fibrillogenesis (10, 11). It also induces epithelial-mesenchymal transition, tumor growth, invasion, and metastasis (9). Periostin induces the expression of VEGF R2 on endothelial cells and VEGF-C in tumor cells, and it can induce tumor lymphangiogenesis (8, 12). Periostin plays an important role in heart valve development and tissue healing after myocardial infarction (5, 13, 14). In asthma, it is upregulated in bronchial epithelium and plays both destructive and protective roles by inducing eosinophil infiltration and inhibiting goblet cell metaplasia and mucus production, respectively (15, 16).

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: Bioassay, Cell Culture, In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using 2955-F2	Applications	Species
Liu, B;Wu, T;Lin, B;Liu, X;Liu, Y;Song, G;Fan, C;Ouyang, G; Periostin-TGF-? feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer British journal of cancer 2023-12-14 [PMID: 38097742] (Bioassay, Human)	Bioassay	Human
Ackerman, JE;Adjei-Sowah, E;Korcari, A;Muscat, SN;Nichols, AEC;Buckley, MR;Loiselle, AE; Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing bioRxiv : the preprint server for biology 2023-07-21 [PMID: 37502924] (Bioassay, Mouse)	Bioassay	Mouse
T Wei, K Wang, S Liu, Y Fang, Z Hong, Y Liu, H Zhang, C Yang, G Ouyang, T Wu Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer Cell Reports, 2023-02-09;42(2):112090. 2023-02-09 [PMID: 36773295] (Bioassay, Mouse)	Bioassay	Mouse
M Tsukasaki, N Komatsu, T Negishi-Ko, NC Huynh, R Muro, Y Ando, Y Seki, A Terashima, W Pluemsakun, T Nitta, T Nakamura, T Nakashima, S Ohba, H Akiyama, K Okamoto, R Baron, H Takayanagi Periosteal stem cells control growth plate stem cells during postnatal skeletal growth Oncogene, 2022-07-18;13(1):4166. 2022-07-18 [PMID: 35851381] (Bioassay, Mouse)	Bioassay	Mouse
Y Ikeda-Iwab, Y Taniyama, N Katsuragi, F Sanada, N Koibuchi, K Shibata, K Shimazu, H Rakugi, R Morishita Periostin Short Fragment with Exon 17 via Aberrant Alternative Splicing Is Required for Breast Cancer Growth and Metastasis Cells, 2021-04-14;10(4):. 2021-04-14 [PMID: 33919736] (Surface Plasmon Resonance, Mouse)	Surface Plasmon Resonance	Mouse
JH Lin, IP Lin, Y Ohyama, H Mochida, A Kudo, M Kaku, Y Mochida FAM20C directly binds to and phosphorylates Periostin Sci Rep, 2020-10-13;10(1):17155. 2020-10-13 [PMID: 33051588] (Bioassay, Human)	Bioassay	Human
SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Cell Rep, 2020-04-07;31(1):107472. 2020-04-07 [PMID: 32268102] (In Vivo, Mouse)	In Vivo	Mouse
H Ma, J Wang, X Zhao, T Wu, Z Huang, D Chen, Y Liu, G Ouyang Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation Cell Rep, 2020-01-21;30(3):793-806.e6. 2020-01-21 [PMID: 31968254] (Bioassay, Mouse)	Bioassay	Mouse
B Gao, R Deng, Y Chai, H Chen, B Hu, X Wang, S Zhu, Y Cao, S Ni, M Wan, L Yang, Z Luo, X Cao Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration J. Clin. Invest., 2019-04-04;129(6):2578-2594. 2019-04-04 [PMID: 30946695] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Ma, X Zhao, M Deng, Z Huang, J Wang, Y Wu, D Cui, Y Liu, R Liu, G Ouyang Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promotes B-ALL Progression by Modulating CCL2 in Leukemia Cells Cell Rep, 2019-02-05;26(6):1533-1543.e4. 2019-02-05 [PMID: 30726736] (Bioassay, Mouse)	Bioassay	Mouse
P Periasamy, V Tran, HC O'Neill Identification of genes which regulate stroma-dependent in vitro hematopoiesis PLoS ONE, 2018-10-11;13(10):e0205583. 2018-10-11 [PMID: 30308055] (Bioassay, Mouse)	Bioassay	Mouse
F Nakazeki, M Nishiga, T Horie, H Nishi, Y Nakashima, O Baba, Y Kuwabara, T Nishino, T Nakao, Y Ide, S Koyama, M Kimura, S Tsuji, N Sowa, S Yoshida, SJ Conway, M Yanagita, T Kimura, K Ono Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo Sci Rep, 2018-06-04;8(1):8553. 2018-06-04 [PMID: 29867212] (Bioassay, Mouse)	Bioassay	Mouse
Y Shimoyama, K Tamai, R Shibuya, M Nakamura, M Mochizuki, K Yamaguchi, Y Kakuta, Y Kinouchi, I Sato, A Kudo, T Shimosegaw, K Satoh Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer Oncotarget, 2018-04-13;9(28):20008-20017. 2018-04-13 [PMID: 29731999] (Bioassay, Mouse)	Bioassay	Mouse
Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H Periostin Is a Key Niche Component for Wound Metastasis of Melanoma. PLoS ONE, 2015-06-17;10(6):e0129704. 2015-06-17 [PMID: 26083413] (Bioassay, Mouse)	Bioassay	Mouse
Yang , Lingli, Murota , Hiroyuki, Serada , Satoshi, Fujimoto , Minoru, Kudo , Akira, Naka , Tetsuji, Katayama , Ichiro Histamine contributes to tissue remodeling via periostin expression. J Invest Dermatol, 2014-02-27;134(8):2105-13. 2014-02-27 [PMID: 24577408] (Bioassay, Mouse)	Bioassay	Mouse
Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K, Simmons O, Toda S, Conway S, Hamasaki Y, Izuhara K Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1alpha/IL-6 loop. J Invest Dermatol, 2013-11-25;134(5):1295-304. 2013-11-25 [PMID: 24352037] (Bioassay, Mouse)	Bioassay	Mouse
Yamashita , Osamu, Yoshimura , Koichi, Nagasawa , Ayako, Ueda , Koshiro, Morikage , Noriyasu, Ikeda , Yasuhiro, Hamano , Kimikazu Periostin links mechanical strain to inflammation in abdominal aortic aneurysm. PLoS ONE, 2013-11-19;8(11):e79753. 2013-11-19 [PMID: 24260297] (Bioassay, Rat)	Bioassay	Rat
Sehra S, Yao W, Nguyen ET, Ahyi AN, Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ, Kaplan MH Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J. Immunol., 2011-03-14;186(8):4959-66. 2011-03-14 [PMID: 21402898] (Bioassay, Mouse)	Bioassay	Mouse
Show All 18 Publications. Collapse Publications.

Array 2955-F2

• Periostin/OSF-2 Antibodies
• Periostin/OSF-2 Antibody Pairs
• Periostin/OSF-2 ELISA Kits
• Periostin/OSF-2 Lysate
• Periostin/OSF-2 Protein
• Periostin/OSF-2 Proteins and Enzymes
• Periostin/OSF-2 ELISAs