Recombinant Mouse IFN-beta Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, ELISA Developmet, In Vivo.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using 12400-1	Applications	Species
A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35181787] (Bioassay, Mouse)	Bioassay	Mouse
A Wang, SD Pope, JS Weinstein, S Yu, C Zhang, CJ Booth, R Medzhitov Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice Proc. Natl. Acad. Sci. U.S.A., 2019-01-23;0(0):. 2019-01-23 [PMID: 30674681] (Bioassay, Mouse)	Bioassay	Mouse
S Li, Z Hong, Z Wang, F Li, J Mei, L Huang, X Lou, S Zhao, L Song, W Chen, Q Wang, H Liu, Y Cai, H Yu, H Xu, G Zeng, Q Wang, J Zhu, X Liu, N Tan, C Wang The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING Cell Rep, 2018-12-18;25(12):3405-3421.e7. 2018-12-18 [PMID: 30566866] (Bioassay, Mouse)	Bioassay	Mouse
H Cui, S Banerjee, S Guo, N Xie, G Liu IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages J. Immunol., 2018-03-21;0(0):. 2018-03-21 [PMID: 29563175] (Bioassay, Mouse)	Bioassay	Mouse
JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation EMBO J., 2018-02-19;0(0):. 2018-02-19 [PMID: 29459437] (Bioassay, Mouse)	Bioassay	Mouse
A McDonough, RV Lee, S Noor, C Lee, T Le, M Iorga, JLH Phillips, S Murphy, T Möller, JR Weinstein Ischemia/Reperfusion Induces Interferon Stimulated Gene Expression in Microglia J. Neurosci., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747383] (In Vivo, Mouse)	In Vivo	Mouse
MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Bioassay, Mouse)	Bioassay	Mouse
Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015-09-28;195(9):4446-55. 2015-09-28 [PMID: 26416280] (Bioassay, Mouse)	Bioassay	Mouse
Majumdar , Tanmay, Chattopadhyay , Saurabh, Ozhegov , Evgeny, Dhar , Jayeeta, Goswami , Ramansu, Sen , Ganes C, Barik , Sailen Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLoS Pathog, 2015-03-26;11(3):e1004779. 2015-03-26 [PMID: 25811886] (Bioassay, Mouse)	Bioassay	Mouse
Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation. J Biol Chem, 2014-08-01;289(38):26642-57. 2014-08-01 [PMID: 25086041] (Bioassay, Mouse)	Bioassay	Mouse
Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol, 2014-03-19;192(8):3618-25. 2014-03-19 [PMID: 24646738] (Bioassay, Mouse)	Bioassay	Mouse
Lu B, Antoine D, Kwan K, Lundback P, Wahamaa H, Schierbeck H, Robinson M, Van Zoelen M, Yang H, Li J, Erlandsson-Harris H, Chavan S, Wang H, Andersson U, Tracey K JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. Proc Natl Acad Sci U S A, 2014-01-27;111(8):3068-73. 2014-01-27 [PMID: 24469805] (Bioassay, Mouse)	Bioassay	Mouse
Munitic I, Giardino Torchia M, Meena N, Zhu G, Li C, Ashwell J Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells. J Immunol, 2013-11-15;191(12):6231-40. 2013-11-15 [PMID: 24244017] (Cell Culture, Mouse)	Cell Culture	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA Evaluating vaccinia virus cytokine co-expression in TLR GKO mice. Immunol. Cell Biol., 2010-12-21;89(0):706-15. 2010-12-21 [PMID: 21173782] (ELISA Developmet, Mouse)	ELISA Developmet	Mouse
Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol., 2010-11-22;186(1):556-62. 2010-11-22 [PMID: 21098223] (Bioassay, Mouse)	Bioassay	Mouse
Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R IFN-gamma down-regulates Secretoglobin 3A1 gene expression. Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8. 2009-01-09 [PMID: 19135978] (Bioassay, Mouse)	Bioassay	Mouse
Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse)	Bioassay	Mouse
Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. J. Immunol., 2007-06-15;178(12):7607-15. 2007-06-15 [PMID: 17548596] (Bioassay, Mouse)	Bioassay	Mouse
Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006-05-23;108(6):2041-4. 2006-05-23 [PMID: 16720837] (Bioassay, Mouse)	Bioassay	Mouse
Zhang F, Lee J, Wang D, Dong Z Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice. J. Interferon Cytokine Res., 2006-02-01;26(2):108-18. 2006-02-01 [PMID: 16487031] (Bioassay, Mouse)	Bioassay	Mouse
Show All 21 Publications. Collapse Publications.

Array 12400-1

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs