Recombinant Mouse CCL3/MIP-1 alpha Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL3, also known as macrophage inflammatory protein 1 alpha (MIP-1 alpha ) and LD78, is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta . Chemokines comprise a large family of small secreted proteins that are involved in immune and inflammatory responses. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells (1). Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively (2). CCL3 is an approximately 8 kDa chemokine that forms complexes with sulfated proteoglycans (3, 4). In a reversible process, CCL3 associates into noncovalently-linked dimers which then form tetramers and high molecular weight polymers (5, 6). These complexes of CCL3 are protected from proteolytic digestion by insulin degrading enzyme (IDE) which can cleave the monomeric chemokine (6). CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5 (1). It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6 (7). CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils (1, 8 - 10). CCL3 is also known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor cells (3). CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis (11 - 14), although it also can suppress the replication of HIV (15). CCL3 additionally promotes hyperalgesia by sensitizing sensory neurons to TRPV1-mediated noxious stimulation (16).

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: Binding Assay, Bioassay, ELISA (Standard), In Vivo.

Showing Publications 1 - 10 of 31. Show All 31 Publications. Collapse Publications.

Publications using 450-MA/CF	Applications	Species
R Roy, J Zayas, SK Singh, K Delgado, SJ Wood, MF Mohamed, DM Frausto, YA Albalawi, TP Price, R Estupinian, EF Giurini, TM Kuzel, A Zloza, J Reiser, SH Shafikhani Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound Elife, 2022-02-03;11(0):. 2022-02-03 [PMID: 35112667] (Bioassay, Mouse)	Bioassay	Mouse
TE Khoyratty, Z Ai, I Ballestero, HL Eames, S Mathie, S Martín-Sal, L Wang, A Hemmings, N Willemsen, V von Werz, A Zehrer, B Walzog, E van Grinsv, A Hidalgo, IA Udalova Distinct transcription factor networks control neutrophil-driven inflammation Nature Immunology, 2021-07-19;0(0):. 2021-07-19 [PMID: 34282331] (Bioassay, Mouse)	Bioassay	Mouse
Y Ishida, Y Kuninaka, M Nosaka, A Kimura, A Taruya, M Furuta, N Mukaida, T Kondo Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis Nat Commun, 2020-11-25;11(1):5994. 2020-11-25 [PMID: 33239616] (In Vivo, Mouse)	In Vivo	Mouse
S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity Front Microbiol, 2019-06-25;10(0):1421. 2019-06-25 [PMID: 31293551] (Binding Assay, Mouse)	Binding Assay	Mouse
ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019-05-20;130(0):2555-2570. 2019-05-20 [PMID: 31107242] (Bioassay, Mouse)	Bioassay	Mouse
JM da Silva, TP Moreira Do, LM Sobral, CM Queiroz-Ju, MA Rachid, AEI Proudfoot, GP Garlet, AC Batista, MM Teixeira, AM Leopoldino, RC Russo, TA Silva Relevance of CCL3/CCR5 axis in oral carcinogenesis Oncotarget, 2017-04-06;8(31):51024-51036. 2017-04-06 [PMID: 28881626] (Bioassay, Mouse)	Bioassay	Mouse
CD84 mediates CLL-microenvironment interactions Oncogene, 2016-07-25;0(0):. 2016-07-25 [PMID: 27452524] (Bioassay, Mouse)	Bioassay	Mouse
Couturier J, Stancu I, Schakman O, Pierrot N, Huaux F, Kienlen-Campard P, Dewachter I, Octave J Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease. J Neuroinflammation, 2016-01-27;13(1):20. 2016-01-27 [PMID: 26818951] (Bioassay, Mouse)	Bioassay	Mouse
Poon G, Dong Y, Marshall K, Arif A, Deeg C, Dosanjh M, Johnson P Hyaluronan Binding Identifies a Functionally Distinct Alveolar Macrophage-like Population in Bone Marrow-Derived Dendritic Cell Cultures. J Immunol, 2015-06-17;195(2):632-42. 2015-06-17 [PMID: 26085682] (Bioassay, Mouse)	Bioassay	Mouse
Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, Benjamim C, Penido C Murine IL-17+ Vgamma4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis. BMC Immunol, 2015-06-03;16(0):36. 2015-06-03 [PMID: 26037291] (Bioassay, Mouse)	Bioassay	Mouse
Mitchell , Duane A, Batich , Kristen, Gunn , Michael, Huang , Min-Nung, Sanchez-Perez , Luis, Nair , Smita K, Congdon , Kendra L, Reap , Elizabet, Archer , Gary E, Desjardins , Annick, Friedman , Allan H, Friedman , Henry S, Herndon , James E, Coan , April, McLendon , Roger E, Reardon , David A, Vredenburgh , James J, Bigner , Darell D, Sampson , John H Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature, 2015-03-11;519(7543):366-9. 2015-03-11 [PMID: 25762141] (In Vivo, Mouse)	In Vivo	Mouse
Sato S, Zhang X The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clin Exp Immunol, 2014-07-01;177(1):102-9. 2014-07-01 [PMID: 24580413] (Bioassay, Mouse)	Bioassay	Mouse
Gonzalvo-Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, Bierschenk S, Sperandio M, Vecchi A, Sozzani S Endothelial cell-derived chemerin promotes dendritic cell transmigration. J Immunol, 2014-01-27;192(5):2366-73. 2014-01-27 [PMID: 24470498] (Bioassay, Mouse)	Bioassay	Mouse
Fujihara Y, Takato T, Hoshi K Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells, 2014-05-01;32(5):1208-19. 2014-05-01 [PMID: 24446149] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Bignon A, Gaudin F, Hemon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol, 2013-12-23;192(3):886-96. 2013-12-23 [PMID: 24367031] (Bioassay, Mouse)	Bioassay	Mouse
Reichel CA, Puhr-Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, Wymann MP, Luckow B, Krombach F C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood, 2012-06-06;120(4):880-90. 2012-06-06 [PMID: 22674804] (In Vivo, Mouse)	In Vivo	Mouse
Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011-10-01;179(6):2730-9. 2011-10-01 [PMID: 21967814] (ELISA (Standard))	ELISA (Standard)
Kim HS, Go H, Akira S, Chung DH TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice. J. Immunol., 2011-09-19;187(8):4007-17. 2011-09-19 [PMID: 21930967] (In Vivo, Mouse)	In Vivo	Mouse
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med., 2009-03-29;15(4):417-24. 2009-03-29 [PMID: 19330010] (Bioassay, Mouse)	Bioassay	Mouse
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J. Immunol., 2008-11-01;181(9):6384-93. 2008-11-01 [PMID: 18941229] (Bioassay, Mouse)	Bioassay	Mouse
Reichel CA, Rehberg M, Bihari P, Moser CM, Linder S, Khandoga A, Krombach F Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling. J. Leukoc. Biol., 2008-01-03;83(4):864-74. 2008-01-03 [PMID: 18174361] (In Vivo, Mouse)	In Vivo	Mouse
Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 2007-12-06;450(7171):825-31. 2007-12-06 [PMID: 18064003] (Bioassay, Mouse)	Bioassay	Mouse
Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamim CF, Henriques MG Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway. Int. Immunol., 2007-12-04;20(1):129-39. 2007-12-04 [PMID: 18056919] (In Vivo, Mouse)	In Vivo	Mouse
Zozulya AL, Reinke E, Baiu DC, Karman J, Sandor M, Fabry Z Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. J. Immunol., 2007-01-01;178(1):520-9. 2007-01-01 [PMID: 17182592] (Bioassay, Mouse)	Bioassay	Mouse
Ramos CD, Fernandes KS, Canetti C, Teixeira MM, Silva JS, Cunha FQ Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur. J. Immunol., 2006-08-01;36(8):2025-34. 2006-08-01 [PMID: 16856209] (ELISA (Standard))	ELISA (Standard)
Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem. Biophys. Res. Commun., 2006-05-12;345(3):1122-30. 2006-05-12 [PMID: 16713992] (Bioassay, Mouse)	Bioassay	Mouse
Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA (Standard))	ELISA (Standard)
Perrin FE, Lacroix S, Aviles-Trigueros M, David S Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain, 2005-02-02;128(0):854-66. 2005-02-02 [PMID: 15689362] (In Vivo, Mouse)	In Vivo	Mouse
Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am. J. Pathol., 2004-12-01;165(6):2187-96. 2004-12-01 [PMID: 15579460] (Bioassay, Rat)	Bioassay	Rat
Reading PC, Symons JA, Smith GL A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection. J. Immunol., 2003-02-01;170(3):1435-42. 2003-02-01 [PMID: 12538705] (ELISA (Standard))	ELISA (Standard)
Menten P, Saccani A, Dillen C, Wuyts A, Struyf S, Proost P, Mantovani A, Wang JM, Van Damme J Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma. J. Leukoc. Biol., 2002-10-01;72(4):780-9. 2002-10-01 [PMID: 12377948] (Bioassay, Mouse)	Bioassay	Mouse
Show All 31 Publications. Collapse Publications.

Array 450-MA/CF

• CCL3/MIP-1 alpha Antibodies
• CCL3/MIP-1 alpha ELISA Kits
• CCL3/MIP-1 alpha Lysate
• CCL3/MIP-1 alpha Proteins
• CCL3/MIP-1 alpha Proteins and Enzymes
• CCL3/MIP-1 alpha ELISAs